摘要
目的:观察益气活血方对射血分数保留型心力衰竭(HFpEF)患者进行干预后,其心功能、脑钠肽(BNP)、超敏C反应蛋白(hs-CRP)的变化情况。方法:将84例HFpEF患者按照随机数字表法分为治疗组和对照组,每组各42例。对照组采用西医标准化治疗方案,治疗组在对照组基础上给予益气活血方治疗,2组疗程均为4周。观察2组治疗前后心功能指标[包括心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左室射血分数(LVEF)、6 min步行试验(6MWT)]、BNP及hs-CRP的变化,并评价综合疗效。结果:总有效率治疗组为90.48%(38/42),对照组为80.95%(34/42),2组比较,差异有统计学意义(P<0.05)。治疗后2组LVESD、LVEDD及血清BNP、hs-CRP水平均较治疗前降低,LVEF较治疗前升高,6MWT较治疗前增加,且治疗组各项指标改善情况均优于对照组,差异均有统计学意义(P<0.05)。结论:益气活血方能够抑制HFpEF患者体内BNP和hs-CRP的表达,改善心功能指标,增加6MWT距离。
Objective:To investigate the changes in cardiac function,brain natriuretic peptide(BNP),and high-sensitivity C-reactive protein(hs-CRP)after intervention with Qi-tonifying and blood-activating prescriptionin patients with heart failure with preserved ejection fraction(HFpEF).Methods:A total of 84 patients with HFpEF were divided into treatment group and control group using a random number table,with 42 patients in each group.The patients in the control group were given standardized Western medicine treatment,and those in the treatment group were given Qi-tonifying and blood-activating prescription in addition to the treatment in the control group;the course of treatment was 4 weeks for both groups.The two groups were observed in terms of the changes in cardiac function parameters[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),and six-minute walk test(6 MWT)],BNP,and hs-CRP,and overall response was evaluated.Results:There was a significant difference in overall response rate between the treatment group and the control group[90.48%(38/42)vs 80.95%(34/42),P<0.05].After treatment,both groups had significant reductions in LVESD,LVEDD,and serum levels of BNP and hs-CRP and significant increases in LVEF and 6 MWT,and the treatment group had significantly better improvements than the control group(P<0.05).Conclusion:For patients with HFpEF,Qi-tonifying and blood-activating prescription can inhibit the expression of BNP and hs-CRP,improve cardiac function parameters,and increase the distance of 6 MWT.
作者
顾亚威
莫云秋
甘程
刘锐
GU Yawei;MO Yunqiu;GAN Cheng;LIU Rui(Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,Guangxi,China)
出处
《湖南中医杂志》
2021年第6期1-4,共4页
Hunan Journal of Traditional Chinese Medicine
基金
广西壮族自治区中医药管理局自筹经费项目(GZZC2019080)。
关键词
射血分数保留型心力衰竭
益气活血方
心功能
脑钠肽
超敏C反应蛋白
heart failure with preserved ejection fraction
Qi-tonifying and blood-activating prescription
cardiac function
brain natriuretic peptide
high-sensitivity C-reactive protein
