摘要
目的探究真实世界中硒酵母片治疗对甲状腺功能(甲功)正常的桥本甲状腺炎患者的影响。方法研究为回顾性研究,选取华中科技大学同济医学院附属同济医院内分泌科门诊诊治的187例甲功正常的桥本甲状腺炎患者为研究对象,均接受硒酵母片治疗,随访6个月,比较患者治疗前后甲状腺抗体[甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)]水平和甲状腺功能[促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))]水平。根据治疗后甲状腺抗体的变化情况将患者进行分组,比较年龄、性别、病程、硒日用剂量及基线抗体水平等各项因素之间的差异。结果经硒酵母片治疗后,TPOAb和TgAb水平在3个月和6个月时显著下降(P<0.05);TSH、FT_(3)、FT_(4)水平治疗6个月后未见明显变化(P>0.05);TPOAb下降的幅度显著高于TgAb的下降幅度(P<0.05)。经硒酵母治疗后TPOAb下降组和非下降组在年龄、性别、病程、硒日用量及基线抗体水平方面均未见明显差异(P>0.05);比较于治疗后TgAb下降组,治疗后TgAb非下降组的年龄均值更大,女性患者占比更高,且基线TgAb浓度均值更低(P<0.05)。不同硒用量组间TPOAb、TgAb的变化并无明显差异(P>0.05)。结论硒酵母片治疗可能有降低桥本甲状腺炎患者的甲状腺抗体水平、改善免疫反应的作用。
Objective To explore the effect of selenium yeast tablets on Hashimoto's thyroiditis patients with normal thyroid function in the real world.Methods A total of 187 Hashimoto's thyroiditis patients with normal thyroid function were treated with selenium yeast tablets and followed up for 6 months.The changes in thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TgAb),thyroid stimulating hormone(TSH),free triiodothyronine(FT_(3)),and free thyroxine(FT_(4))before and after treatment were retrospectively analyzed.The patients were divided into groups according to the changes in thyroid antibodies after treatment,and the differences among various factors such as age,gender,the course of disease,daily dose of selenium,and levels of baseline antibody were compared.Results After the treatment with selenium yeast tablets,the levels of TPOAb and TgAb decreased significantly after 3 months of treatment and after 6 months of treatment(P<0.05),but the levels of TSH,FT_(3),and FT_(4)showed no significant changes after 6 months of treatment(P>0.05).The decreased amplitude of TPOAb was significantly higher than that of TgAb(P<0.05).There was no significant difference in the percentage of the decreases of TPOAb and TgAb between the first 3 months of treatment and the following 3 months of treatment(P>0.05).There was no significant differences in age,sex,course of disease,daily selenium dosage,and levels of baseline antibody between people whose TPOAb decreased after selenium yeast treatment and those whose TPOAb did not decrease(P>0.05).Compared with the patients whose TgAb decreased after treatment,the patients whose TgAb did not decrease after treatment had a larger mean age,a higher proportion of female patients,and a lower mean baseline concentration of TgAb(P<0.05).There was no significant difference in the changes of both TPOAb and TgAb between the groups treated by different selenium dosage(P>0.05).Conclusion Selenium yeast tablets treatment may reduce the levels of thyroid antibodies and improve the immune response
作者
韩夏
刘喆隆
HAN Xia;LIU Zhelong(Department of Endocrinology,Tongji Hospital,Tongji Medical College,Huazhong University Science and Technology,Wuhan 430030,China)
出处
《医药导报》
CAS
北大核心
2021年第8期1065-1069,共5页
Herald of Medicine
关键词
硒酵母片
桥本甲状腺炎
甲状腺抗体
真实世界研究
Selenium yeast tablets
Hashimoto's thyroiditis
Thyroid antibody
Real-world study
