摘要
目的:探讨ⅢB型前列腺炎患者脑结构网络节点局部与全局效率拓扑属性值的改变情况,并分析不同脑区信息传递效率与患者骨盆区域疼痛不适相关性。方法:入组19例ⅢB型前列腺炎患者和32例一般人口学资料匹配的正常对照者,使用美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评估患者骨盆区域疼痛,并对其进行大脑结构相和弥散相核磁共振扫描,利用FSL软件包和BCT工具箱对被试大脑核磁共振数据进行预处理、脑结构网络构建以及节点局部与全局效率拓扑属性值的计算,最后使用SPSS 20软件对组间数据进行双样本t检验,并使用错误发现率(FDR)方法对节点属性值差异结果进行多重比较校正,同时对组间差异脑区效率属性值与NIH-CPSI评分进行Pearson相关性分析。结果:全局效率:患者组脑白质网络右侧额中回眶部(患者组vs对照组:0.095±0.046 vs 0.13±0.015)全局效率属性值显著下降,而左侧扣带回中部(0.16±0.027 vs 0.14±0.019)全局效率属性值显著上升,差异均存在统计学意义,并通过FDR校正;局部效率:患者组脑白质网络左侧扣带回中部(0.25±0.075 vs 0.19±0.036)、旁中央小叶(0.25±0.088 vs 0.17±0.065)局部效率属性值显著上升,差异均存在统计学意义,通过FDR校正。患者组脑白质网络中左侧楔前叶(r=0.46;P=0.045)、右侧补充运动区(r=0.47;P=0.043)、左侧扣带回中部局部(r=0.60;P=0.0065)效率属性值分别与NIH-CPSI量表总分、疼痛和不适症状评分以及症状对生活质量的影响评分呈正相关。结论:ⅢB型前列腺炎患者大脑执行控制相关脑区的改变,可能参与增加其大脑对疼痛不适的感受体验,进而导致患者出现一系列骨盆区域疼痛不适。
Objective:To investigate the changes in the topological properties of the global and local nodal efficiencies of the brain white matter network in patients with type Ⅲ B prostatitis,and to analyze the correlation between the information transmission efficiency of different brain regions and pelvic pain.Methods:We enrolled 19 patients with type ⅢB prostatitis and 32 normal controls matched in general demographic data for this study.We assessed the pelvic pain of the patients based on the NIH-CPSI,obtained the structural and diffusion-weighted MR images of the brain,preprocessed the MRI data,constructed the brain structural networks and calculated the topological properties of the nodal local and global efficiencies using the FSL software package and brain connection toolbox.Finally,we compared the topological properties between the two groups by t-test with the SPSS 20 software,performed multiple correction of the values using the false discovery rate(FDR)method,and investigated the associations of the altered brain regions with the NIH-CPSI scores by Pearson correlation analysis.Results:The global efficiency of the orbital part of the right median frontal gyrus in the patients with type ⅢB prostatitis,compared with that in the normal controls,was dramatically decreased(0.095±0.046 vs 0.13±0.015,P<0.01)while that of the left median cingulate gyrus markedly increased(0.16±0.027 vs 0.14±0.019,P<0.01),which were corrected by FDR.The local efficiency of the left median cingulate gyrus was also remarkably decreased in the patients as compared with that in the controls(0.25±0.075 vs 0.19±0.036,P<0.01),and so was that of the left paracentral lobule(0.25±0.088 vs 0.17±0.065,P<0.01),which were corrected by FDR.In the patients,the local efficiencies of the left precuneus(r=0.46,P=0.045),right supplementary motor area(r=0.47,P=0.043)and left median cingulate gyrus(r=0.60,P=0.0065)were positively correlated with the total score of NIH-CPSI,the scores of pain and discomfort symptoms,and the scores of the influenc
作者
徐琰
杨朝旭
陈建淮
巩庆阔
刘涛
刘绍伟
陈赟
薛建国
黄新飞
XU Yan;YANG Zhao-xu;CHEN Jian-huai;GONG Qing-kuo;LIU Tao;LIU Shao-wei;CHEN Yun;XUE Jian-guo;HUANG Xin-fei(Department of Andrology,Jiangsu Province Hospital of Chinese Medicine/The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210029,China;Department of Urology,Pizhou Hospital of Chinese Medicine,Xuzhou,Jiangsu 221300,China;Department of Radiology,Jiangsu Province Hospital of Chinese Medicine/The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210029,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2021年第5期410-415,共6页
National Journal of Andrology
基金
江苏省六大人才高峰项目(2015-WSN-050)
江苏省“333”工程培养对象资助项目(LGY2016016)。
