摘要
目的分析经皮椎间孔镜治疗对腰椎间盘突出症患者细胞因子水平的影响。方法选取2017年12月至2020年10月本院收治的112例腰椎间盘突出症患者,根据医嘱中的手术方式不同分为对照组(传统椎板开窗术治疗)和实验组(经皮椎间孔镜治疗)各56例,另选取60例同期于本院接受健康体检人群作为健康组,比较不同人群间活性氧簇(ROS)、丙二醛(MDA)、髓过氧化物酶(MPO)等应激指标和血清肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)以及白介素-1(IL-1)等炎性因子水平,并比较对照组和实验组术后临床疗效、应激指标、炎性因子水平及并发症情况。结果健康组ROS、MDA、MPO等应激指标及TNF-α、IL-1、IL-6等炎性因子水平均低于对照组和实验组,差异均有统计学意义(P<0.05)。术后两组ROS、MDA、MPO水平及TNF-α、IL-1、IL-6水平较术前均有明显下降,差异均有统计学意义(P<0.05)。对照组临床总疗效(87.50%)低于实验组临床总疗效(98.21%),差异有统计学意义(P<0.05)。对照组并发症率为10.71%,实验组并发症率为8.93%,比较差异无统计学意义(P>0.05)。结论经皮椎间孔镜手术疗效佳,可降低腰椎间盘突出症患者的应激水平及炎症水平,且术后无严重并发症出现,安全性高,值得推广应用。
Objective To analyze the effect of percutaneous transforaminal endoscopic discectomy on the cytokine levels of patients with lumbar intervertebral disc protrusion. Method 112 patients with lumbar intervertebral disc protrusion treated in this hospital from December 2017 to October 2020 were selected.According to different surgical methods in the doctor. s order,they were divided into the control group(traditional laminectomy treatment) and the experimental group(percutaneous transforaminal endoscopic discectomy),56 cases in each group. In addition,60 healthy people who had health examinations in this hospital during the same period were selected as the healthy group. The stress indicators [reactive oxygen species(ROS),malondialdehyde(MDA),myeloperoxidase(MPO)]and inflammatory factor levels[serum tumor necrosis factor-α(TNF-α),interleukin 6(IL-6)and interleukin-1(IL-1)]between different groups were compared. The clinical efficacy,stress indicators,inflammatory factor levels and complications were compared between the control group and the experimental group. Result The levels of inflammatory factors such as TNF-α,IL-1,IL-6 and stress indicators such as ROS,MDA and MPO in the healthy group were lower than those in the control group and the experimental group,and the difference was statistically significant(P<0.05). The levels of ROS,MDA,MPO and TNF-α,IL-1,and IL-6 in the 2 groups after surgery significantly decreased,and the difference was statistically significant(P<0.05). Among them,and the difference was statistically significant(P<0.05). The total clinical efficacy of the control group(87.50%)was lower than that(98.21%)in the experimental group,and the difference was statistically significant(P<0.05). The incidence of complications in the control group was 10.71% and that in the experimental group was 8.93%. There was no statistical difference in the incidence of complications between the two groups(P>0.05). Conclusion Percutaneous transforaminal endoscopic discectomy has a good effect,can reduce the stress
作者
张强泽
亓佳慧
谢学生
秦飞
亓强
ZHANG Qiangze;QI Jiahui;XIE Xuesheng;QIN Fei;QI Qiang(Department of Pain,Jinan People's Hospital,Shandong First Medical University,Jinan,Shandong,China,271100)
出处
《分子诊断与治疗杂志》
2021年第6期897-900,904,共5页
Journal of Molecular Diagnostics and Therapy
基金
山东省青年科学家基金(BS2017YY025)。
