摘要
目的了解2014-2019年间该院儿童患者分离出的金黄色葡萄球菌(SA)的分布情况及耐药变迁,为临床治疗提供依据。方法对该院2014年1月至2019年12月期间从儿童患者送检标本中分离出的SA的分布及耐药性进行回顾性分析,使用VITEK2 COMPACT全自动细菌鉴定及药敏分析系统对分离出的SA进行鉴定和药敏试验。结果共分离出1636株SA,检出年龄段主要集中在0~1个月和1个月至1岁两个年龄段,分别占29.9%和46.7%,1636株SA的分布来源前5位的是门诊、新生儿科、心血管儿科、消化儿科以及儿科ICU,分别占22.9%、21.7%、17.4%、14.4%及12.7%。标本来源首位是痰(79.0%),其次是全血、咽拭子、脓、分泌物。1636株SA中耐甲氧西林金黄色葡萄球菌(MRSA)376株,检出率为23.0%,耐药率较高的抗菌药物主要是青霉素(94.9%)、红霉素(62.3%)、克林霉素(61.3%),对其他的药物有较高的敏感性,SA中尚未发现对万古霉素、利奈唑胺和替加环素耐药的菌株。MRSA对青霉素、环丙沙星、克林霉素、利福平、四环素、红霉素的耐药率均高于甲氧西林敏感金黄色葡萄球菌(MSSA),但对庆大霉素和复方磺胺的耐药率低于MSSA。结论儿童患者分离出的SA以MSSA为主,总体耐药率较低,但SA分离率有上升的趋势,应予以特别关注。
Objective To analyze the clinical distribution and changes of antimicrobial resistance profiles of staphylococcus aureus(SA)isolated from pediatric patients of Hubei Jianghan Oilfield General Hospital from 2014 to 2019,so as to provide references for clinical treatment.Methods Retrospective review was performed to analyze the clinical distribution and changes of antimicrobial resistance of SA isolated from from pediatric patients from January 2014 to December 2019,the train identification and drug susceptibility test were performed by VITEK2 COMPACT automatic microorganism identification system.Results A total of 1636 strains of SA were isolated.The detection age mainly concentrated in 0-1 month and 1 month to 1 year old,accounting for 29.9%and 46.7%respectively.The top five sources of 1636 strains of SA were outpatient,neonatal,cardiovascular,digestive and pediatric ICU,accounting for 22.9%,21.7%,17.4%,14.4%and 12.7%respectively.Sputum was the first source of specimens(79.0%),followed by whole blood,throat swab,pus and secretion.Among 1636 strains of SA,376 strains were methicillin-resistant staphylococcus aureus(MRSA),with a detection rate of 23.0%.Penicillin(94.9%),erythromycin(62.3%)and clindamycin(61.3%)were the main antibiotics with high resistance rate,and they were highly sensitive to other drugs.No strains resistant to vancomycin,linezolid and tigecycline were found in SA.The resistance rates of MRSA to penicillin,ciprofloxacin,clindamycin,rifampicin,tetracycline and erythromycin were higher than that of methicillin sensitive staphylococcus aureus(MSSA),but the resistance rates to gentamicin and compound sulfanilamide were lower than that of MSSA.Conclusion The total drug resistance rate of SA isolated from children is mainly MSSA,but the separation rate of SA is rising,so special attention should be paid to.
作者
张洁
ZHANG Jie(Hubei Jianghan Oilfield General Hospital,Qianjiang,Hubei 433121,China)
出处
《国际检验医学杂志》
CAS
2021年第S01期102-105,共4页
International Journal of Laboratory Medicine
