摘要
目的探讨妊娠期女性B族链球菌(GBS)感染状况及其抗生素治疗对母婴结局的影响。方法选取2018年1月-2020年9月收治的妊娠期女性500例,均接受GBS筛查。分析妊娠期女性GBS感染状况和感染风险因素,以及GBS阳性妊娠期女性抗生素治疗情况。根据是否感染GBS将入选的妊娠期女性500例分为观察组(GBS阳性,142例)和对照组(GBS阴性,358例)两组,根据是否接受抗生素治疗将GBS阳性妊娠期女性分为治疗组(82例)和未治疗组(60例)两组。比较观察组和对照组、治疗组和未治疗组妊娠结局和新生儿结局。结果体质量≥70 kg、有流产史、文化程度初中及以下和有生殖道感染史妊娠期女性GBS阳性率较高(P<0.01)。观察组胎膜早破、早产、宫内感染和真菌性阴道炎发生率高于对照组;治疗组产褥期感染和真菌性阴道炎发生率低于未治疗组,差异有统计学意义(P<0.05或P<0.01)。观察组新生儿低体质量、窒息、肺炎、病理性黄疸和脓毒症发生率均高于对照组;治疗组新生儿窒息、肺炎、病理性黄疸和脓毒症发生率均低于未治疗组,差异有统计学意义(P<0.05或P<0.01)。结论体质量、流产史、文化程度和生殖道感染史均与妊娠期女性发生GBS感染密切相关,制定合适的抗生素治疗方案对改善GBS感染妊娠期女性不良母婴结局至关重要。
Objective To investigate the infection conditions of group B streptococcus(GBS)in pregnant women and effects of antibiotic treatment on maternal and infant outcomes.Methods A total of 500 pregnant women admitted between January 2018 and September 2020 were selected and underwent GBS screening.Conditions of GBS infection and risk factors for infection in pregnant women,as well as the conditions of antibiotic treatment for GBS-positive pregnant women were analyzed.The 500 pregnant women were divided into observation group(positive GBS,n=142)and control group(negative GBS,n=358)according to presence or absence of GBS infection.In addition,GBS positive pregnant women were divided treatment subgroup(n=82)and non-treatment subgroup(n=60)according to whether or not having antibiotic treatment.The pregnancy and neonatal outcomes were compared between observation and control groups,and between treatment and non-treatment subgroups.Results Higher GBS positive rate was observed in pregnant women with body mass index(BMI)equal or more than 70 kg,history of abortion,middle school education or lower,and history of reproductive tract infection(P<0.01).Incidence rates of premature rupture of membranes,premature delivery,intrauterine infection and fungal vaginitis in observation group were significantly higher than those in control group,and incidence rates of puerperal infection and fungal vaginitis in treatment subgroup were significantly lower than those in non-treatment subgroup(P<0.05 or P<0.01).Incidence rates of low neonatal BMI,asphyxia,pneumonia,pathological jaundice and sepsis in observation group were significantly higher than those in control group,and incidence rates of neonatal asphyxia,pneumonia,pathological jaundice and sepsis in treatment subgroup were significantly lower than those in non-treatment subgroup(P<0.05 or P<0.01).Conclusion BMI,history of abortion,educational background and infection history of reproductive tract are closely related to GBS infection in pregnant women.It is important to make appropria
作者
付永会
高继
FU Yong-hui;GAO Ji(Department of Obstetrics,Guihang Guiyang Hospital,Guiyang 550001,China)
出处
《临床误诊误治》
CAS
2021年第7期76-80,共5页
Clinical Misdiagnosis & Mistherapy
基金
贵州省计生委科学技术基金项目(gzwjkj2018-1-050)。
关键词
妊娠
B族链球菌
感染
抗生素预防
妊娠结局
新生儿结局
Pregnancy
Group B streptococcal
Infection
Antibiotic prophylaxis
Pregnancy outcome
Neonatal outcome
