摘要
目的观察健胃消胀片对慢性萎缩性胃炎(CAG)模型大鼠血清超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量的影响。方法将SPF级雄性大鼠随机分为正常组、模型组、阳性对照组(胃复春)和健胃消胀片低、中、高剂量组,采用脱氧胆酸钠、水杨酸钠交替灌胃并以单功能烷化剂甲基硝基亚硝基胍(MNNG)作为饮用水造CAG模型,连续给药7周后观察血清中SOD活性和MDA含量变化。结果经7周治疗后,健胃消胀片中剂量组与正常组对比,SOD活性升高(P<0.05)。健胃消胀片各组的MDA含量比正常组、模型组均有所下降,健胃消胀片各组与模型组比较,差异有统计学意义(P<0.05);中剂量组与正常组比较差异有统计学意义(P<0.05)。结论健胃消胀片在CAG模型大鼠治疗过程中,通过升高SOD活性,降低MDA含量参与CAG氧化与抗氧化环节,从而起到保护胃黏膜的作用,同时健胃消胀片各剂量组均能降低MDA含量,故在CAG疾病过程中,健胃消胀片具有阻止细胞向胃癌转变的作用。
Objective To observe the effect of Jianwei Xiaozhang Tablets on Superoxide dismutase(SOD)activity and malondialdehyde(MDA)content in Serum of Model Rats with Chronic Atrophic Gastritis.Methods SPF male rats were randomly divided into normal group,model group,positive control group(Weifuchun)and the low,middle and high dose Jianwei Xiaozhang Tablets group.Model Rats with Chronic Atrophic Gastritis were made by means of sodium deoxycholate and sodium salicylate alternately injected into the stomach and using monofunctional alkylating agent methyl phosphite nitro guanidine nitrate(MNNG)as the drinking water.Results After 7 weeks of treatment,SOD activity in the middle dose Jianwei Xiaozhang Tablets group was increased in the dose group and the normal group,with statistical significance(P<0.05).MDA content of Jianwei Xiaozhang Tablets in each group was decreased in comparison with that in the model group,with statistical significance in comparison with the model group(P<0.05),and that in the medium dose group with that in the normal group(P<0.05).Conclusion In the treatment process of CAG model rats,Jianwei Xiaozhang Tablets participate in CAG oxidation and antioxidant link by increasing SOD activity and reducing MDA content,thus playing a role in protecting gastric mucosa,At the same time,Jianwei Xiaozhang Tablets can reduce MDA content in all dose groups,which are statistically significant,Therefore,in the process of CAG disease,Jianwei Xiaozhang Tablets can prevent the transformation of cells into gastric cancer.
作者
邓艳华
董明国
DENG Yanhua;DONG Mingguo(Department of Gastroenterology,Dongguan Hospital of Traditional Chinese Medicine,Dongguan,Guangdong 523000,China)
出处
《重庆医学》
CAS
2021年第S01期21-24,共4页
Chongqing medicine
关键词
慢性萎缩性胃炎
健胃消胀片
超氧化物歧化酶
丙二醛
大鼠
Chronic atrophic gastritis
Jianwei xiaozhang tablets
Superoxide dismutase
Malondialdehyde
Rat
