摘要
目的观察双合汤治疗类风湿关节炎急性发作期(痰瘀痹阻证)的疗效以及对血瘀状态的改善作用。方法选取类风湿关节炎急性发作期(痰瘀痹阻证)患者90例,按随机数字表法分为对照组与观察组各45例。对照组行氨甲蝶呤片治疗,观察组在对照组治疗基础上以双合汤内服,疗程为2周。比较两组风湿性关节炎活动度量表(DAS28)评分、血沉(ESR)、类风湿因子(RF)、痰瘀痹阻证评分、临床疗效以及血瘀状态指标,包括血小板激活因子(PAF)、PAF-乙酰水解酶(PAF-AH)、血小板(PLT)水平。结果治疗后,观察组DAS28评分、ESR、RF以及痰瘀痹阻证症状评分明显低于对照组(P<0.01),血瘀状态指标PAF、PAF-AH、PLT改善均明显优于对照组(P<0.01),观察组总有效率显著高于对照组(P<0.05)。结论双合汤治疗类风湿关节炎痰瘀痹阻证的疗效确切,且能够改善患者的血瘀状态。
Objective:To investigate the efficacy of Shuanghe Decoction in treating acute stage of rheumatoid arthritis(syndrome of phlegm and stasis blockade)and its improvement role on blood stasis state.Methods:90 acute stage of rheumatoid arthritis(syndrome of phlegm and stasis blockade)cases were selected and divided into the control group and observation group according to random number table method,45 cases in each group.The control group received methotrexate tablets.In the observation group,on the basis of the treatment in the control group,Shuanghe Decoction was taken with 1 dose/d taken twice.The course of treatment was for 2 weeks for both groups.The activity score of rheumatoid arthritis(DAS28),erythrocyte sedimentation rate(ESR),and rheumatoid factor(RF),scores of main symptoms of obstruction of phlegm and blood stasis type,efficacy,and blood stasis indicators including levels of platelet activating factor(PAF),PAF-acetylhydrolase(PAF-AH)and platelet(PLT)were compared between the two groups.Results:After treatment,DAS28,ESR,RF,scores of symptoms of syndrome of obstruction of phlegm and blood stasis type of the observation group were significantly lower than those of the control group(P<0.01).The total effective rate of the observation group was obviously higher than that of the control group(P<0.05).After treatment,the improvement of blood stasis indexes such as PAF,PAF-AH and PLT in the observation group was significantly better than those in the control group(P<0.01).Conclusion:The efficacy of Shuanghe Decoction for rheumatoid arthritis patients with syndrome of phlegm and stasis blockade is significant,and can effectively improve blood stasis state.
作者
张翠霞
尹谢添
梅应兵
邓阿黎
Zhang Cuixia;Yin Xietian;Mei Yingbing;Deng Ali(Hubei Provincial Hospital of Traditional Chinese Medicine,Hubei,Wuhan 430061,China)
出处
《中国中医急症》
2021年第7期1237-1240,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
2017年度湖北省高等学校优秀中青年科技创新团队(T201708)。
关键词
类风湿性关节炎
痰瘀痹阻证
血瘀状态
双合汤
Rheumatoid arthritis
Syndrome of phlegm and blood stasis
Blood stasis state
Shuanghe Decoction
