摘要
目的评价清营汤联合丙种球蛋白治疗川崎病的临床效果。方法选取本院于2019年1月至2020年1月收治的28例川崎病患儿,根据患儿是否采用清营汤治疗将其分为清营汤组(6例)和常规西医组(22例)。清营汤组男5例,女1例,年龄(2.23±1.80)岁;常规西医组男15例,女7例,年龄(1.65±1.09)岁。常规西医组予丙种球蛋白及阿司匹林治疗,清营汤组在常规西医组治疗基础上加用口服清营汤治疗。观察两组患儿的症状消失时间、免疫功能水平及实验室相关指标。结果清营汤组患儿入院发热、手足肿胀、眼结膜充血、皮疹消退时间分别为(1.88±0.19)d、(2.27±0.12)d、(2.75±1.84)d、(2.92±1.69)d,均短于常规西医组(2.64±0.50)d、(3.90±2.14)d、(5.29±1.94)d、(5.02±2.32)d,差异均有统计学意义(均P<0.05)。清营汤组患儿免疫球蛋白A(IgA)水平高于常规西医组[1.12(0.67,2.35)g/L比0.50(0.35,1.20)g/L],差异有统计学意义(P<0.05);两组患儿IgG、IgM水平比较,差异均无统计学意义(均P>0.05)。清营汤组患儿炎性指标[血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)、降钙素原(PCT)、血沉(ESR)]水平与常规西医组比较,差异均无统计学意义(均P>0.05)。结论清营汤联合丙种球蛋白治疗川崎病可改善患儿免疫功能,缩短临床症状消失时间。
Objective To evaluate the clinical effect of Qingying decoction combined with gamma globulin in the treatment of Kawasaki disease.Methods Twenty-eight children with Kawasaki disease admitted to our hospital from January 2019 to January 2020 were selected and were divided into a Qingying decoction group(6 cases)and a conventional western medicine group(22 cases)according to whether the children were treated with Qingying decoction or not.In the Qingying decoction group,there were 5 males and 1 female,with an age of(2.23±1.80)years old;in the conventional western medicine group,there were 15 males and 7 females,with an age of(1.65±1.09)years old.The conventional western medicine group was treated with gamma globulin and aspirin,and the Qingying decoction group was treated with oral Qingying decoction on the basis of the conventional western medicine group.The time of symptom disappearance,immune function levels,and laboratory related indicators of the two groups were observed.Results The disappearance time of fever,hand and foot swelling,conjunctival congestion,and rashes in the Qingying decoction group were(1.88±0.19)d,(2.27±0.12)d,(2.75±1.84)d,and(2.92±1.69)d,which were shorter than those in the conventional western medicine group[(2.64±0.50)d,(3.90±2.14)d,(5.29±1.94)d,and(5.02±2.32)d](all P<0.05).The level of immunoglobulin A(IgA)in the Qingying decoction group was higher than that in the conventional western medicine group[1.12(0.67,2.35)g/L vs.0.50(0.35,1.20)g/L](P<0.05);there were no statistically significant differences in IgG and IgM levels between the two groups(both P>0.05).There were no statistically significant differences in the levels of serum amyloid A(SAA),C-reactive protein(CRP),procalcitonin(PCT),and erythrocyte sedimentation rate(ESR)between the two groups(all P>0.05).Conclusion Qingying decoction combined with gamma globulin can improve the immune function of children with Kawasaki disease and shorten the disappearance time of clinical symptoms.
作者
张宙
赖来清
罗秋燕
杨丽霞
郭惠娴
廖嘉仪
Zhang Zhou;Lai Laiqing;Luo Qiuyan;Yang Lixia;Guo Huixian;Liao Jiayi(Pediatric Internal Medicine,Guangzhou Yuexiu District Children's Hospital,Guangzhou 510115,China;Preventive Treatment Department,Guangzhou Yuexiu District Children's Hospital,Guangzhou 510115,China)
出处
《国际医药卫生导报》
2021年第14期2121-2124,共4页
International Medicine and Health Guidance News
基金
广州市越秀区科技计划项目(2019-WS-016)。
关键词
川崎病
清营汤
丙种球蛋白
免疫球蛋白
Kawasaki disease
Qingying decoction
Gamma globulin
Immunoglobulin
