摘要
目的观察高胆红素血症早期新生儿的脑功能变化。方法58例高胆红素血症患儿,均于入院后行振幅整合脑电图(aEEG)检测,分析脑电背景活动周期性指标[3 h内的睡眠—觉醒周期(SWC)数量、单个SWC持续时间、下边界电压、带宽、窄带宽、窄带时长占比]变化。抽取外周静脉血检测血清总胆红素、白蛋白,测算血清总胆红素与白蛋白比值(B/A)。结果58例患儿中3 h内SWC数量≤2组22例(A组)和3 h内SWC数量>2组36例(B组)。A组下边界电压(5.43±1.43)μV、带宽(24.58±7.73)μV、窄带宽(7.00±1.94)μV,1个SWC中窄带时长占比0.71±0.05;B组下边界电压(5.64±1.15)μV、带宽(25.92±7.72)μV、窄带宽(7.17±2.32)μV,1个SWC中窄带时长占比0.64±0.72。与B组比较,A组1个SWC中窄带时长占比高(P<0.05)。A组血清总胆红素峰值(402.92±43.03)μmol/m L,血清白蛋白(36.92±2.10)g/L,B/A值4.40±0.74;B组血清总胆红素峰值(378.13±29.35)μmol/m L,血清白蛋白(36.47±2.97)g/L,B/A值6.10±0.64;与B组比较,A组血清总胆红素水平升高(P<0.05)。结论高胆红素血症新生儿早期即出现脑电背景活动周期性改变。高胆红素血症早期即可造成新生儿睡眠功能变化。
Objective To observe the changes of brain function in neonates with hyperbilirubinemia in the early stage.MethodsAmplitude-integrated electroencephalogram(a EEG)was performed in 58 children with hyperbilirubinemia after admission.The changes of a EEG background activity periodic indexes[number of sleep-wake cycles(SWC)within 3 h,duration of single SWC,lower boundary voltage,bandwidth,narrow bandwidth,and proportion of narrow bandwidth duration]were analyzed.Peripheral venous blood of the children was collected to detect serum total bilirubin and albumin,and we calculated the ratio of serum total bilirubin to albumin(B/A).ResultsAmong the58 children,there were 22 cases in the group A with SWC less than or equal to 2 within 3 h,and 36 cases in the group B with SWC more than 2 within 3 h.The lower boundary voltage,bandwidth,narrow bandwidth,and the proportion of narrow band time in one SWC of the group A were(5.43±1.43)μV,(24.58±7.73)μV,(7.00±1.94)μV and 0.71±0.05.The lower boundary voltage,bandwidth,narrow bandwidth and the proportion of narrow band time in one SWC of group B were(5.64±1.15)μV,(25.92±7.72)μV,(7.17±2.32)μV and 0.64±0.72.Compared with group B,the proportion of narrow band duration in one SWC in the group A was higher(P<0.05).In the group A,the peak value of serum total bilirubin was(402.92±43.03)μmol/m L,serum albumin was(36.92±2.10)g/L,B/A value was 4.40±0.74;in the group B,the peak value of serum total bilirubin was(378.13±29.35)μmol/m L,serum albumin was(36.47±2.97)g/L,B/A value was 6.10±0.64.Compared with group B,the level of serum total bilirubin in group A increased(P<0.05).ConclusionsThe periodic changes of a EEG background activity occurred in the early stage of neonates with hyperbilirubinemia.The sleep function of neonatal brain tissues may change at the early stage of hyperbilirubinemia.
作者
常贺生
田润雨
鞠俊
黄淑霞
郑婧
秦选光
CHANG Hesheng;TIAN Runyu;JU Jun;HUANG Shuxia;ZHENG Jing;QIN Xuanguang(Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)
出处
《山东医药》
CAS
2021年第18期25-28,共4页
Shandong Medical Journal
基金
北京市医院管理中心儿科学科协同发展中心专项经费资助项目(XTYB201814)。
关键词
脑损伤
高胆红素血症
新生儿
振幅整合脑电图
睡眠—觉醒周期
brain damage
hyperbilirubinemia
neonates
amplitude-integrated electroencephalogram
sleep-wake cycle
