摘要
目的探究泮托拉唑治疗消化性溃疡合并上消化道出血的临床效果。方法100例消化性溃疡合并上消化道出血患者,随机分为观察组和对照组,各50例。观察组给予泮托拉唑治疗,对照组给予奥美拉唑治疗。比较两组治疗效果,出血时间、输血量、胃液pH值及血红蛋白、C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-1β(IL-1β)、白细胞介素-2(IL-2)水平,不良反应发生情况。结果观察组出血时间短于对照组,输血量少于对照组,胃液pH值、血红蛋白水平均高于对照组,差异具有统计学意义(P<0.05)。观察组治疗总有效率98.00%高于对照组的74.00%,差异有统计学意义(P<0.05)。治疗后,观察组CRP(0.35±0.08)ng/ml、PCT(0.24±0.01)ng/ml均低于对照组的(0.42±0.12)、(0.31±0.02)ng/ml,差异有统计学意义(P<0.05)。治疗后,观察组IL-1β(0.30±0.02)ng/ml、IL-2(0.27±0.08)ng/ml均低于对照组的(0.38±0.05)、(0.33±0.01)ng/ml,差异有统计学意义(P<0.05)。观察组不良反应发生率2.00%低于对照组的24.00%,差异有统计学意义(P<0.05)。结论消化性溃疡合并上消化道出血患者采用泮托拉唑治疗效果十分显著,且不良反应发生率低,值得研究和推广。
Objective To investigate the clinical effect of pantoprazole in the treatment of peptic ulcer complicated with upper gastrointestinal bleeding.Methods A total of 100 cases of peptic ulcer complicated with upper gastrointestinal bleeding were randomly divided into observation group and control group,with 50 cases in each group.The observation group was treated with pantoprazole,and the control group was treated with omeprazole.The therapeutic effect,bleeding time,blood transfusion volume,gastric juice pH,hemoglobin,C-reactive protein(CRP),procalcitonin(PCT),interleukin-1β(IL-1β),interleukin-2(IL-2),and occurrence of adverse reactions were compared between the two groups.Results The bleeding time of the observation group was shorter than that of the control group,blood transfusion volume was less than that of the control group,and gastric juice pH and hemoglobin were higher than those of the control group.All the difference was statistically significant(P<0.05).The total effective rate 98.00%of the observation group was higher than 74.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the CRP(0.35±0.08)ng/ml and PCT(0.24±0.01)ng/ml of the observation group were lower than(0.42±0.12)and(0.31±0.02)ng/ml of the control group,and the different was statistically significant(P<0.05).After treatment,the IL-1β(0.30±0.02)ng/ml and IL-2(0.27±0.08)ng/ml of the observation group were lower than(0.38±0.05)and(0.33±0.01)ng/ml of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 2.00%of the observation group was lower than 24.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion Pantoprazole has significant effect on patients with peptic ulcer and upper gastrointestinal bleeding with low incidence of adverse reactions,which is worthy of research and promotion.
作者
高向君
林萌
GAO Xiang-jun;LIN Meng(Gastroenterology Department,Dongchangfu Branch of Liaocheng People’s Hospital,Liaocheng 252000,China)
出处
《中国现代药物应用》
2021年第13期11-14,共4页
Chinese Journal of Modern Drug Application
关键词
泮托拉唑
奥美拉唑
消化性溃疡合并上消化道出血
Pantoprazole
Omeprazole
Peptic ulcer complicated with upper gastrointestinal bleeding
