摘要
目的监测中性粒细胞-血小板比值(Neutrophil to platelet ratio,NPR)对直接行PCI术的急性ST段抬高型心肌梗死患者(STEMI)术后出现主要心血管不良事件(Major adverse cardiovascular events,MACE)的预测价值。方法选取2018年1月-2019年12月期间在广州医科大学附属第三医院诊断为急性ST段抬高型心肌梗死并行直接PCI术的患者175例,将患者分为2组,NPR>0.045为高比值组78例,NPR≤0.045为低比值组105例。比较2组患者住院期间及出院后一年内发生MACE事件的发生率。结果175例STEMI患者住院期间出现MACE事件的发生率为11.42%,其中,高NPR组为14.10%,低NPR组为9.28%,两组患者MACE事件发生率有统计学差异(P<0.05)。患者在一年的随访期间,MACE事件发生率为18.85%,其中,高NPR组为23.07%,低NPR组为15.46%,两组患者MACE事件发生率有统计学差异(P<0.05)。吸烟、合并糖尿病,LVEF降低,年龄、肌酐、LDL-C及NPR升高为PCI术后STEMI患者发生MACE事件的独立危险因素。结论中性粒细胞-血小板比值对STEMI患者术后一年内发生MACE事件有预测价值,可指导STEMI患者的危险分层,利于个体化治疗。
Objective To evaluate the predictive value of neutrophil to platelet ratio(NPR)for major adverse cardiovascular events(MACE)in patients with acute ST-segment elevation myocardial infarction(STEMI)undergoing primary PCI.Methods From January 2018 to December 2019,175 patients with acute ST-segment elevation myocardial infarction(STEMI)who underwent primary PCI in the Third Affiliated Hospital of Guangzhou Medical University were selected and divided into two groups,78 patients with NPR>0.045 and 105 patients with NPR≤0.045.The incidence of MACE during hospitalization and one year after discharge was compared between the two groups.Results The incidence of MACE in 175 STEMI patients during hospitalization was 11.42%,among them,14.10%in high NPR group and 9.28%in low NPR group.There was significant difference in the incidence of MACE between the two groups(P<0.05).During the one-year follow-up period,the incidence of MACE was 18.85%,of which 23.07%was in the high NPR group and 15.46%was in the low NPR group.There was significant difference in the incidence of MACE between the two groups(P<0.05).Smoking,diabetes,decreased LVEF,and increased age,creatinine,LDL-C and NPR were independent risk factors for MACE in STEMI patients after PCI.Conclusion The neutrophil platelet ratio has predictive value for MACE events in STEMI patients within one year after operation,which can guide the risk stratification of STEMI patients and facilitate individualized treatment.
作者
周蕾
毛孟常
林育辉
ZHOU Lei;MAO Mengchang;LIN Yuhui(The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China;不详)
出处
《现代医院》
2021年第6期979-981,984,共4页
Modern Hospitals
基金
广东省中医药局科研项目(20202135)
广州医科大学大学生实验室开放项目(2018)。
