摘要
目的探讨中性粒细胞/淋巴细胞比值(neutrophil-lymphocyte ratio,NLR)与系统性红斑狼疮(systemic lupus erythematosus,SLE)患者肾脏损害的相关性。方法选取昆明医科大学第一附属医院风湿免疫科确诊的SLE患者共410例。根据有无肾脏损害,分为非狼疮肾炎组(非LN组)和狼疮肾炎组(LN组),比较2组NLR的差异,分析NLR与狼疮患者肾脏损害的相关性。结果 LN组NLR显著高于非LN组的SLE患者,差异有统计学意义(P <0.05)。SLE患者的NLR分别与白细胞计数、中性粒细胞计数、血肌酐、血尿素、ESR、CRP、PCT、24 h尿蛋白呈正相关,与淋巴细胞计数、总蛋白、白蛋白、球蛋白呈负相关。结论 NLR可作为评估SLE患者肾脏损害的一项辅助指标。
Objective To evaluate the association between neutrophil-lymphocyte ratio(NLR)and renal damage in patients with systemic lupus erythematosus(SLE).Methods A total of 410 patients with SLE from the Department of Rheumatology and Immunology of the First Affiliated Hospital of Kunming Medical University were selected.According to whether accompanied by renal involvement,patients with SLE were divided into non-lupus nephritis group(non-LN group)and lupus nephritis group(LN group).The differences in NLR between the two groups were compared,and the correlation between NLR and renal damage was analyzed.Results The NLR of LN group was significantly higher than that of SLE patients in non-LN group,and the difference wsa statistically significant(P<0.05).The NLR of SLE patients were positively correlated with leukocyte count,neutrophils count,serum creatinine,blood urea nitrogen,ESR,CRP,PCT and 24-hour urine protein,and negatively correlated with lymphocyte count,total protein,albumin and globulin,respectively.Conclusion NLR can be used as an auxiliary index to evaluate renal damage in SLE patients.
作者
廖莉
娄雪
赵若彤
王湘宇
杨一帆
刘爽
徐健
LIAO Li;LOU Xue;ZHAO Ruo-tong;WANG Xiang-yu;Yang Yi-fan;LIU Shuang;XU Jian(Dept.of Rheumatology and Immunology,the First Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)
出处
《昆明医科大学学报》
CAS
2021年第6期72-75,共4页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81760296
81460256)
风湿免疫性疾病多中心临床科研转化平台基金资助项目(2018ZF016)
云南省医疗卫生单位内设研究机构科研基金资助项目(2018NS0133)
云南省皮肤免疫疾病临床医学研究中心基金资助项目(2019ZF012)。
