摘要
目的探讨生脉散合归脾汤对2型糖尿病(T2DM)急性肾损伤气阴两虚证的治疗作用及机制。方法将120例T2DM急性肾损伤气阴两虚证患者随机分为对照组和观察组各60例;两组患者均给予饮食控制等基础治疗,对照组在基础治疗基础上给予盐酸二甲双胍片和盐酸贝那普利,观察组在对照组基础上加服生脉散合归脾汤。比较两组患者的临床疗效、中医证候评分、血糖、炎症因子、肾功能、血液流变学、症状和体征消失时间及安全性。结果观察组治疗总有效率高于对照组(P<0.05);治疗后,观察组患者的各中医证候评分均低于对照组(P<0.05);观察组的症状和体征消失时间均少于对照组(P<0.05);观察组的血糖、肾功能、炎症因子及血液流变学指标均明显优于对照组(P<0.05);两组未见明显不良反应发生。结论生脉散合归脾汤治疗T2DM急性肾损伤气阴两虚证患者疗效明显,可能与改善血液流变学和肾功能,减少蛋白尿有关,安全性高。
Objective To explore the clinical effect and mechanism of Shengmai San and Guipi Tang on Type 2 Diabetes Mellitus(T2DM)patients with acute kidney injury for deficiency of qi and yin.Methods120 T2DM patients with acute kidney injury for deficiency of qi and yin are randomly divided into control group(60 cases)and observation group(60 cases);the control group is given metformin hydrochloride tablets and benazepril hydrochloride while the observation group is given Shengmai San and Guipi Tang.The clinical efficacy,TCM syndrome score,blood glucose level,renal function index,inflammatory factor level,hemorheology index,symptom disappearance time,and safety evaluation are compared between the two groups.Results The total effective rate of the observation group is significantly higher than which of the control group(P<0.05);after treatment,the scores of all TCM syndromes of the observation group are lower than those of the control group(P<0.05);the disappearance time of symptoms and signs are shorter than which of the control group(P<0.05);the blood glucose,renal function,inflammatory factors and hemorheological indexes of the observation group are significantly better than those of the control group(P<0.05);no obvious adverse reactions are observed in the two groups.Conclusion Shengmai San and Guipi Tang has significant effect on T2DM patients with acute kidney injury for deficiency of qi and yin,which may be related to improving hemorheology and renal function,reducing proteinuria,and has good safety.
作者
都增强
康文娟
蒲蔚荣
刘香春
DU Zeng-qiang;KANG Wen-juan;PU Wei-rong;LIU Xiang-chun(Department of Endocrinology,Qinghai Hospital of Traditional Chinese Medicine,Xining 810000,China;College of Medical,Qinghai University,Xining 810001,China)
出处
《现代中药研究与实践》
CAS
2021年第3期70-74,共5页
Research and Practice on Chinese Medicines
基金
国家中医药管理局中医药防治重大疑难疾病临床服务能力建设项目(201312)
国家中医药管理局第五批全国老中医药专家学术经验继承工作项目(国中医药人教函[2012]123号)。
关键词
生脉散合归脾汤
2型糖尿病
急性肾损伤
气阴两虚
临床疗效
作用机制
Shengmai San and Guipi Tang
type 2 diabetes
acute kidney injury
deficiency of qi and yin
clinical efficacy
mechanism
