摘要
目的探讨瘢痕子宫合并前置胎盘外周血血管内皮生长因子(VEGF)、可溶性酪氨酸激酶受体-1(sFIt-1)的水平及意义。方法选取2019年1月~2020年11月于无锡怡和妇产医院进行治疗的218例瘢痕子宫孕妇作为研究对象,其中76例合并前置胎盘孕妇作为观察组,142例未合并前置胎盘孕妇作为对照组。检测两组的VEGF、SFIt-1水平,采用Pearson分析观察组患者外周血VEGF和sFIt-1水平的关系,比较两组的母婴结局。结果观察组的外周血VEGF为(71.60±24.66)ng/mL,低于对照组的(192.41±35.57)ng/mL,差异有统计学意义(P<0.05);观察组的sFIt-1为(2.98±0.91)ng/mL,高于对照组的(1.20±0.45)ng/mL,差异有统计学意义(P<0.05);瘢痕子宫合并前置胎盘孕妇的外周血VEGF与SFIt-1水平呈负相关(r=-0.594,P<0.05);观察组的剖宫产、产后出血、胎盘植入及子宫切除发生率分别为100.00%、38.16%、23.68%和7.89%,高于对照组的68.31%、12.68%、6.34%和0.00%,差异有统计学意义(P<0.05);观察组的新生儿窒息、早产儿发生率分别19.74%和64.47%,高于对照组的4.23%和35.92%,差异有统计学意义(P<0.05)。结论瘢痕子宫合并前置胎盘孕妇的外周血VEGF降低,而sFIt-1升高,两者间存在相关性,瘢痕子宫合并前置胎盘孕妇的不良妊娠结局发生率更高。
Objective To investigate the levels and significant of vascular endothelial growth factor(VEGF)and soluble tyrosine kinase receptor-1(sFIt-1)in peripheral blood of scarred uterus with placenta previa.Methods A total of 218 cases of pregnant women with scarred uterus treated in Wuxi Yihe Obstetrics and Gynecology Hospital from January 2019 to November 2020 were selected as the research subjects.Among them,76 pregnant women with placenta previa were taken as the observation group,and 142 pregnant women without placenta previa were taken as the control group.VEGF and SFIt-1 levels in the two groups were detected,Pearson was used to analyze the relationship between VEGF and SFIt-1 levels in peripheral blood of the observation group,and the maternal and infant outcomes of the two groups were compared.Results The VEGF in peripheral blood of the observation group was(71.60±24.66)ng/mL,which was lower than that of the control group of(192.41±35.57)ng/mL,the difference was statistically significant(P<0.05).The SFIt-1 of the observation group was(2.98±0.91)ng/mL,which was higher than that of the control group of(1.20±0.45)ng/mL,and the difference was statistically significant(P<0.05).The levels of VEGF and SFIt-1 in peripheral blood of pregnant women of scarred uterus with placenta previa were negatively correlated(r=-0.594,P<0.05).The incidence rates of cesarean section,postpartum hemorrhage,placenta implantation and hysterectomy in the observation group were 100.00%,38.16%,23.68%and 7.89%,respectively,which were higher than those in the control group(68.31%,12.68%,6.34%and 0.00%),the differences were statistically significant(P<0.05).The incidence rates of neonatal asphyxia and premature infants in the observation group were 19.74%and 64.47%,respectively,which were higher than those in the control group(4.23%and 35.92%),the differences were statistically significant(P<0.05).Conclusion There is a correlation between the decrease of VEGF and the increase of SFIt-1 in peripheral blood of pregnant women of scarred uterus
作者
蒋丽蓉
黄晓平
徐乙玉
JIANG Li-rong;HUANG Xiao-ping;XU Yi-yu(Department of Obstetrics,Wuxi Yihe Obstetrics and Gynecology Hospital,Jiangsu Province,Wuxi214000,China;Department of Obstetrics,Wuxi Maternal and Child Health Hospital,Jiangsu Province,Wuxi214000,China;Department of Obstetrics and Gynecology,Dujiangyan Medical Center,Sichuan Province,Dujiangyan611830,China)
出处
《中国当代医药》
CAS
2021年第18期102-105,共4页
China Modern Medicine
