摘要
肿瘤可通过多种机制逃避机体免疫系统的识别和杀伤。腺苷通路在肿瘤免疫逃逸过程中扮演着重要角色。腺苷由胞外三磷酸腺苷(ATP)在CD39和CD73两种外核酸酶的作用下产生,经与腺苷受体[主要为腺苷A2A受体(A2AR)]结合而发挥效应。在肿瘤微环境中,腺苷通路被过度激活可诱导免疫抑制信号,促进肿瘤的发生和发展。该文对腺苷通路调节肿瘤免疫的作用及其潜在的临床应用价值进行总结,并对当前腺苷通路相关靶向药物的研究证据进行总结和评价,旨在为深入认识腺苷通路在肿瘤领域的意义提供参考。
A variety of mechanisms help tumor escape from the recognition and killing by the body immune system.In recent years,the adenosine pathway has been found to play an important role in tumor immune evasion.Adenosine is produced from extracellular adenosine triphosphate(ATP)in the presence of two ectonucleotidases(CD39 and CD73),and exerts specific functions through binding to its receptors[mainly adenosine A2A receptor(A2AR)].Studies have suggested that the adenosine pathway can be over-activated in the tumor micro-environment,and thus promoting tumor development and progression by generating the immuno-suppressive signals.This review talked about the role of the adenosine pathway in regulating tumor immunity and its potential clinical application value.At the same time,the latest research evidence of adenosine-pathway-related targeted drugs is evaluated and summarized to provide a comprehensive reference for understanding the significance of the adenosine pathway in cancer management.
作者
俞阳
张安琪
高磊
尹振宇
刘乾
白玉萍
刘乐
齐文博
陈昊
Yu Yang;Zhang An-Qi;Gao Lei;Yin Zhen-Yu;Liu Qian;Bai Yu-Ping;Liu Le;Qi Wen-Bo;Chen Hao(Department of Tumor Surgery,Lanzhou University Second Hospital,Lanzhou 730030,China;Department of Tumor Surgery,the Second Clinical Medical College of Lanzhou University,Lanzhou 730030,China;Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100191,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2021年第6期616-622,共7页
Medical Journal of Chinese People's Liberation Army
基金
甘肃省重点人才项目(2019RCXM020)
兰州市城关区科技计划项目(2019RCCX0034)
兰州大学第二医院“萃英科技创新”计划项目(CY2017-ZD01)。
