摘要
目的:本研究旨在通过比较骨质疏松症患者常见中医证候所对应的骨代谢标志物表达的差异,为辨证客观化与临床研究提供依据。方法:2018年3月至6月在北京市长辛店地区现场采集194例45~80岁女性及50~80岁男性中医证候、骨代谢标志物的相关信息,并比较不同证候骨质疏松症人群骨代谢标志物之间的差异。结果:194例骨质疏松症患者男性25例,女性169例,平均年龄(65.39±6.53)岁,其中中医证候辨证属肾阳虚证42例,肝肾阴虚证71例,脾肾阳虚证66例,血瘀气滞证15例。血瘀气滞证患者25(OH)D3水平显著低于肾阳虚证、肝肾阴虚证患者,差异有统计学意义(P<0.05);脾肾阳虚证患者25(OH)D3水平显著低于肾阳虚证患者,差异有统计学意义(P<0.05);血瘀气滞证、肾阳虚证患者骨钙素水平显著高于肝肾阴虚证患者,差异有统计学意义(P<0.01)。结论:骨质疏松症患者的骨代谢指标与血瘀气滞证、脾肾阳虚证、肾阳虚证等中医证候密切相关,尤其是血瘀气滞证为疾病的高应答状态,临床治疗时应关注活血化瘀药物的应用,现有结果仍然需要扩大样本量进一步验证。
Objective:The purpose of this study is to compare the expression of bone metabolic markers corresponding to common TCM syndromes in patients with osteoporosis and to provide basis for objective syndrome differentiation and clinical research.Methods:From March to June 2018,the relevant information of TCM syndromes and bone metabolic markers of 194 women aged 45 and 80 years old and men aged 50 years and 80 years old in Changxindian area of Beijing were collected,and the differences of bone metabolic markers in people with osteoporosis of different syndromes were compared.Results:Among the 194 patients with osteoporosis,there were 25 males and 169 females,with an average age of(65.39±6.53)years.There were 42 cases of kidney Yang deficiency syndrome,71 cases of liver and kidney Yin deficiency syndrome,66 cases of spleen and kidney Yang deficiency syndrome and 15 cases of blood stasis and Qi stagnation syndrome.The level of 25(OH)D3 in patients with blood stasis and qi stagnation syndrome was significantly lower than that in patients with kidney Yang deficiency syndrome and liver-kidney yin deficiency syndrome,the level of 25(OH)D3 in patients with spleen-kidney Yang deficiency syndrome was significantly lower than that in patients with kidney-Yang deficiency syndrome,and the level of osteocalcin in patients with blood stasis-Qi stagnation syndrome and kidney-Yang deficiency syndrome was significantly higher than that in patients with liver-kidney Yin deficiency syndrome.Conclusion the indexes of bone metabolism in patients with osteoporosis are closely related to TCM syndromes such as blood stasis and Qi stagnation syndrome,spleen and kidney Yang deficiency syndrome and kidney Yang deficiency syndrome,especially blood stasis and Qi stagnation syndrome is a high response state of the disease.Attention should be paid to the application of drugs for promoting blood circulation and removing blood stasis in clinical treatment.The existing results still need to be further verified by expanding the sample size.
作者
申浩
蒋红岩
章轶立
张成
支英杰
孙凯
王旭
方圣杰
谢雁鸣
魏戌
SHEN Hao;JIANG Hong-yan;ZHANG Yi-li;ZHANG Cheng;ZHI Ying-jie;SUN Kai;WANG Xu;FANG Sheng-jie;XIE Yan-ming;WEI Xu(Changxindian Community Health Service Center,Beijing 100072,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China)
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2021年第6期970-972,1046,共4页
JOURNAL OF BASIC CHINESE MEDICINE
基金
国家中医临床研究基地业务建设第二批科研专项(JDZX2015076)-中医综合干预方案预防原发性骨质疏松症骨折的前瞻性队列研究
北京市中医药科技发展资金青年项目(QN2016-02)—北京长辛店地区女性绝经后骨密度与骨转换标志物的相关性研究
北京市丰台区卫生健康系统研究项目(2018-24)-长辛店地区50~80岁女性常驻居民骨质疏松性骨折风险预测工具研究
中华中医药学会(2017~2019年度)青年人才托举工程项目(CACM-2017-QNRC2-A03)
国家自然科学基金青年基金项目(81904067)-基于“齿为骨之余”理论探索补肾中药调控SDF-1/CXCR4参与骨髓间充质干细胞归巢及成骨分化的效应机制
中国中医科学院基本科研业务费(Z0651)-利用现代医学阐释“齿为骨之余“的变化趋势。
关键词
骨质疏松症
证候
中医
骨代谢标志物
骨密度
Osteoporosis
Syndrome
Traditional Chinese medicine
Bone metabolism markers
Bone mineral density
