摘要
目的:评价宫颈人乳头瘤病毒(HPV)E6/E7mRNA联合薄层液基细胞学检查(TCT)对未明确意义的非典型鳞状上皮细胞(ASCUS)的诊断意义。方法:选择2016年8月-2019年8月本院宫颈癌筛查妇女120例,均接受HPV E6/E7mRNA、TCT检查,以阴道镜活检结果为金标准,评估HPV E6/E7mRNA、TCT检查ASCUS的诊断效能。结果:120例宫颈癌筛查患者中,经阴道镜活检结果确诊为ASCUS 52例,未见肿瘤细胞(NILM)68例。以阴道镜活检结果为金标准,E6/E7mRNA+TCT对ASCUS的诊断灵敏度(94.2%)、特异度(88.2%)、准确度(90.8%)、阳性预测值(86.0%)及阴性预测值(95.2%)均高于E6/E7mRNA、TCT单一检测(P<0.05)。结论:HPV E6/E7mRNA、TCT检查在ASCUS中均有一定诊断意义,联合诊断效能更高,可为临床诊断、治疗提供更多的参考依据,提高宫颈癌早期病变的筛查准确率。
Objective: To evaluate the diagnostic significance of cervical human papillomavirus(HPV) E6/E7 mRNA combined with thin-layer liquid-based cytology(TCT) for population shunt of women with atypical squamous cells of unclear significance(ASCUS). Methods: 120 women who were screened for cervical cancer were selected in this study from August 2016 to August 2019, and all of them had accepted HPV E6/E7 mRNA test and TCT. Based on the gold standard of colposcopy biopsy results, the diagnostic efficacy of HPV E6/E7 mRNA alone, TCT alone, or HPV E6/E7 mRNA combined with TCT for ASCUS was evaluated. Results: Among the 120 women after cervical cancer screening, 52 women were diagnosed as ASCUS, and there were 68 women without tumor cells(NILM). Based on the gold standard of colposcopy biopsy results, the diagnostic sensitivity(94.2%), the specificity(88.2%), the accuracy(90.8%), the positive predictive value(86.0%), and the negative predictive value(95.2%) for diagnosing ASCUS by E6/E7 mRNA combined with TCT were significant higher than those by E6/E7 mRNA alone or TCT alone(P<0.05). Conclusion: Both HPV E6/E7 mRNA and TCT have certain diagnostic significance in the population shunt of the women with ASCUS, but the combined diagnostic efficiency of HPV E6/E7 mRNA and TCT is higher, which can provide more reference for clinical diagnosis and treatment, and can improve the accuracy of screening cervical cancer early.
作者
吴翡斐
WU Feifei(Jinhua People's Hospital,Zhejiang Province,321000)
出处
《中国计划生育学杂志》
2021年第6期1247-1249,共3页
Chinese Journal of Family Planning
