摘要
目的应用实时三维斑点追踪成像(RT3D-STI)技术定量评价左心室射血分数(LVEF)正常的早发性卵巢功能不全(POI)女性亚临床左心室心肌收缩功能改变。方法选取2018年10月至2019年9月于四川省人民医院就诊的LVEF正常的POI患者54例(POI组)和同期来院体检的年龄、身高、体质量相匹配的健康女性志愿者42例(对照组)。2组均进行常规经胸超声心动图检查获得常规左心室构型及功能参数,同时进行RT3D-STI检查获得三维左心室收缩功能参数:整体纵向应变(GLS)、整体圆周应变(GCS)、整体面积应变(GAS)及整体径向应变(GRS)、三维左心室射血分数(3D-LVEF)。比较2组参数的差异。结果POI组舒张末期室间隔厚度(IVST)较对照组增大(P<0.05)。POI组E、E/A、e侧壁均较对照组降低(P<0.01或P<0.05),POI组MPI较对照组增高(P<0.01),2组间比较二维左心室射血分数(2D-LVEF)差异无统计学意义(P>0.05)。POI组GLS、GCS、GAS、GRS均较对照组减低(P均<0.01),2组间比较3D-LVEF差异无统计学意义(P>0.05)。结论LVEF正常的POI女性可能已存在亚临床左心室心肌收缩功能受损。与常规参数LVEF相比,RT3D-STI三维应变参数可更敏感地检测POI女性亚临床左心室心肌收缩功能受损,其可作为评价POI女性早期左心室心肌收缩功能受损的无创检查方法。
Objective To quantitatively evaluate the changes of subclinical left ventricular myocardial systolic dysfunction in premature ovarian insufficiency(POI)women with normal left ventricular ejection fraction(LVEF)using real-time three-dimensional speckle tracking imaging(RT3D-STI).Methods Fifty-four women with normal LVEF diagnosed as having POI were employed as a POI group,and 42 healthy women with matched age,height,and body mass were enrolled as a control group.Both groups underwent conventional transthoracic echocardiography to obtain conventional left ventricular geometric and functional parameters,while RT3D-STI was performed to obtain the three-dimensional left ventricular myocardial systolic function parameters:Global longitudinal strain(GLS),global circumferential strain(GCS),global area strain(GAS),global radial strain(GRS),and three-dimensional left ventricular ejection fraction(3D-LVEF).The differences of the above parameters between the two groups were compared.Results The end-diastolic interventricular septal thickness in the POI group was significantly larger than that in the control group(P<0.05).The values of E,E/A,and lateral e in the POI group were significantly lower than those in the control group(P<0.01 or P<0.05).The myocardial performance index in the POI group was significantly higher than that in the control group(P<0.01).There was no significant difference in two-dimensional left ventricular ejection fraction(2D-LVEF)between the two groups(P>0.05).The GLS,GCS,GAS,and GRS were significantly decreased in the POI group compared to the control group(P<0.01),but there was no significant difference in 3D-LVEF between the two groups(P>0.05).Conclusion The left ventricular myocardial systolic function might be impaired subclinically in POI women with normal LVEF.Compared with LVEF,three-dimensional strain parameters of RT3D-STI can be more sensitive to assess the subclinical changes of left ventricular myocardial systolic function for POI women,indicating that RT3D-STI could be used as a non-invas
作者
王玉琳
尹立雪
李梅
吴越
郭智宇
Wang Yulin;Yin Lixue;Li Mei;Wu Yue;Guo Zhiyu(Department of Ultrasonic Diagnosis,Chengdu Second People's Hospital,Chengdu 610017,China;Department of Cardiovascular Ultrasound and Cardiac Function,Chengdu 610072,China;Department of Obstetrics and Gynecology,Chengdu 610072,China;Department of Pharmacy,Sichuan People's Hospital&Sichuan Academy of Medical Sciences,Chengdu 610072,China;GE Healthcare Group Ultrasound Clinical Education Department,Chengdu 600731,China)
出处
《中华医学超声杂志（电子版）》
CSCD
北大核心
2021年第6期590-596,共7页
Chinese Journal of Medical Ultrasound(Electronic Edition)
关键词
超声心动描记术
斑点追踪成像
早发性卵巢功能不全
心室功能
左
心肌收缩
Echocardiography
Speckle tracking imaging
Premature ovarian insufficiency
Ventricular function,left
Myocardial contraction
