摘要
在65℃恒温条件下,将2,4,6,8,10,12-六硝基六氮杂异戊兹烷(CL-20)与1-甲基-3,4,5-三硝基吡唑(MTNP)按照摩尔比1∶1混合后加入有机溶剂,采用降温结晶法制得CL-20/MTNP共晶。利用高效液相色谱仪测定了CL-20/MTNP共晶及其单组分在甲醇中的溶解度,同时测得308.15K条件下CL-20在不同含量MTNP甲醇溶液中的浓度,通过计算得到308.15K条件下CL-20/MTNP共晶在甲醇溶液中的溶度积常数及溶液络合常数,绘制了CL-20/MTNP共晶在甲醇溶液中的相溶解度图,为共晶的筛选、制备和放大等研究提供了参考。
The 2,4,6,8,10,12-hexanitrohexaazaisopentane(CL-20)/1-methyl-3,4,5-trinitropyrazole(MTNP)cocrystal was prepared by mixing CL-20 and MTNP solids at the molar ratio of 1∶1 into organic solvent under the constant temperature of 65℃,or namely cooling crystallization method.The solubility of CL-20/MTNP cocrystal and its components in methanol were determined via high performance liquid chromatography analysis.Meanwhile,the concentrations of CL-20 at the presence of various amount of MTNP in methanol at 308.15 Kwere also determined.The solubility product constant and the complexation constant of CL-20/MTNP cocrystal in methanol at 308.15 K was acquired by calculations,which can be used to depict the phase solubility diagram.The further insights into the screening,preparation and scaling-up of energetic cocrystals were provided.
作者
唐璐钖
王天楚
单军辉
刘天生
张晋红
Tang Luyang;Wang Tianchu;Shan Junhui;Liu Tiansheng;Zhang Jinhong(School of Environment and Safety Engineering,North University of China,Taiyuan 030051)
出处
《化工新型材料》
CAS
CSCD
北大核心
2021年第6期174-178,183,共6页
New Chemical Materials
关键词
共晶
溶解度
络合常数
相溶解度图
cocrystal
solubility
complexation constant
phase solubility diagram
