摘要
目的:探讨妊娠期糖尿病(GDM)患者孕期及产褥期脂肪细胞因子、炎症因子表达特征。方法:选取2019年10月-2020年10月在本院产科265例GDM孕妇为观察组,正常妊娠孕妇200例为对照组,在孕期、产褥期测定血清炎症因子、脂肪细胞因子水平,对比分析其与胰岛素抵抗指数(HOMA-IR)的相关性。结果:与对照组相比,观察组孕期血清CRP、TNF-α、IL-6及HOMA-IR值更高(P<0.05)。观察组产后血清TNF-α、IL-6及HOMA-IR值均呈下降趋势,CRP呈先升高后下降趋势,孕期、产后3d、产后42d血清CRP、TNF-α、IL-6及HOMA-IR值比较均有差异(P<0.05)。与对照组相比,观察组孕期脂联素水平更低,瘦素、Vaspin水平更高,观察组孕期、产后3d、产后42d脂联素呈升高趋势,瘦素、Vaspin均呈下降趋势(均P<0.05)。相关分析显示,GDM患者孕期脂联素与HOMA-IR呈负相关,瘦素、Vaspin、CRP、TNF-α、IL-6与HOMA-IR均呈正相关(均P<0.05);产后3d、42d,脂联素均与HOMA-IR呈负相关,瘦素、Vaspin、TNF-α、IL-6均与HOMA-IR呈正相关(均P<0.05),CRP与HOMA-IR无显著相关性(P>0.05)。结论:脂肪细胞因子、炎症因子表达参与了GDM的病理生理过程,其水平与产褥期胰岛素抵抗程度密切相关,对产后胰岛素抵抗有一定预测价值。
Objective: To investigate the expression characteristics of adipocytokines and inflammatory factors of the women with gestational diabetes mellitus(GDM) during pregnancy and puerperium. Methods: 265 pregnant women with GDM were selected in study group and 200 normal pregnant women were selected in control group from October 2019 to October 2020. The adipocytokines and inflammatory factors of the women in the two groups were detected during pregnancy and puerperium, and their correlation with the insulin resistance index(HOMA-IR) was analyzed. Results: The levels of serum CRP, TNF-α, IL-6, and HOMA-IR of the women during pregnancy in the study group were significant higher than those of the women in the control group(P<0.05). The serum levels of TNF-α, IL-6 and HOMA-IR of the women in the study group had showed a downward trend, while their CRP level had showed upward trend and then downward trend. The serum levels of CRP, TNF-α, IL-6, and HOMA-IR of the women in the study group were significant different during pregnancy, on the postpartum 3 rd day, and on the postpartum 42 th day(P<0.05). Compared with those of the women in the control group, the adiponectin level of the women in the study group during pregnancy was significant lower, and the levels of leptin and vaspin were significant higher. The adiponectin level of women during pregnancy, on the postpartum 3 rd day, and on the postpartum 42 th day had showed downward an upward trend, while the levels of leptin and Vaspin had showed downward trend(all P<0.05). Correlation analysis showed that the adiponectin level of the women with GDM during pregnancy was negative correlated with their HOMA-IR value, while the levels of leptin, vaspin, CRP, TNF-α, and IL-6 were positive correlated with their HOMA-IR value(all P<0.05). The adiponectin level of the women with GDM on the postpartum 3 rd day and the 42 th day was also negative correlated with their HOMA-IR value, and the levels of leptin, vaspin, CRP, TNF-α, and IL-6 were positive correlated with their HOMA
作者
李哲立
雷美紅
陈建明
林小英
马绍凤
LI Zheli;LEI Meihong;CHEN Jianming;LIN Xiaoying;MA Shaofeng(Hospital of Joint Logistics Support Force,Zhangzhou,Fujian Province,363000)
出处
《中国计划生育学杂志》
2021年第5期1032-1036,共5页
Chinese Journal of Family Planning
关键词
妊娠期糖尿病
产褥期
炎症因子
脂肪细胞因子
胰岛素抵抗
预测
Gestational diabetes mellitus
Puerperium
Inflammatory factors
Adipocytokines
Insulin resistance
Prediction
