摘要
Phagocytosis and innate immune responses to solid structures are topics of interest and debate.Alum,monosodium urate,calcium pyrophosphate dehydrate,silica and by extension all solid entities draw varying degrees of attention from phagocytes,such as antigen presenting cells.For some,innocuous soluble metabolites turn into fierce irritants upon crystallization,pointing to divergent signaling mechanisms of a given substance in its soluble and solid states.Over the years,many mechanisms have been proposed,including phagocytic receptors,toll like receptors,and NACHT-LRRs(NLRs),as well as several other protein structure mediated recognition of the solids.
基金
funded by the National Institutes of Health,USA(No.R21AI089963 and R01AI098995)
Canadian Institutes of Health Research(No.MOP-119295)
Natural Sciences and Engineering Research Council of Canada(No.RGPIN/355350)。
