摘要
【目的】探讨脊柱相关参数和老年骨质疏松症(senile osteoporosis,SOP)临床特征与老年骨质疏松性骨折(osteoporotic fracture,OF)发生风险的关系。【方法】选取本院2018年4月至2020年4月收治的82例老年OF患者作为研究对象(观察组);另外选取本院同期收治的82例SOP患者作为对照(对照组)。两组均于治疗前收集性别、年龄、身体质量指数(BMI)、居住地区、是否吸烟、是否饮酒、有无户外运动、有无家族骨折史、既往有无骨折史、文化程度、骨密度、脊柱相关参数[胸椎后凸角(TK)、胸腰后凸角(TLK)、腰椎前凸角(LL)]各项基础资料信息,通过ROC分析骨密度及TK、TLK、LL预测SOP患者并发OF的价值,再将两组有差异信息纳入多因素Logistic回归分析,行量化赋值,明确SOP患者并发OF的危险因素。【结果】两组性别、居住地区、家族骨折史、文化程度对比差异无统计学意义(P>0.05);观察组年龄≥75岁、BMI<18.5 kg/m^(2)、吸烟、饮酒、无户外运动、既往有骨折史患者占比显著高于对照组,差异有统计学意义(P<0.05);观察组TK、TLK水平显著高于对照组,骨密度、LL水平显著低于对照组,差异有统计学意义(P<0.05)。经ROC分析证实骨密度及TK、TLK、LL能够用于SOP患者并发OF的预测,AUC分别为0.716、0.882、0.863、0.831(均P<0.05)。多因素Logistic回归分析证实,年龄≥75岁、BMI<18.5 kg/m^(2)、吸烟、饮酒、无户外运动、既往有骨折史、骨密度≤0.695 g/cm^(2)、TK≥33.550°、TLK≥23.985°、LL≤31.450°为SOP患者并发OF的危险因素(P<0.05)。【结论】SOP患者并发OF的危险因素较多,其中TK、TLK、LL为其重要的危险因素,临床医师应当予以密切关注。
【Objective】To investigate the relationship between spine related parameters,clinical characteristics of senile osteoporosis(SOP)and the risk of osteoporotic fracture.【Methods】A total82 cases of elderly of patients in our hospital from April 2018 to April 2020 were selected as the research objects(observation group);In addition,82 patients with SOP in our hospital during the same period were selected as the control group.Before treatment,the basic data of gender,age,body mass index(BMI),residential area,smoking,drinking,outdoor sports,family fracture history,previous fracture history,education level,bone mineral density,and spinal parameters[thoracic kyphosis angle(TK),thoracolumbar kyphosis angle(TLK),lumbar lordosis angle(LL)]were collected,ROC was used to analyze the value of bone mineral density,TK,TLK and LL in predicting of of patients with SOP,and then the difference information between the two groups was included in the multivariate logistic regression analysis for quantitative evaluation,so as to determine the risk factors of of of patients with SOP.【Results】There was no significant difference in gender,living area,family fracture history and education level between the two groups(P>0.05);The proportion of patients with age≥75 years old,BMI<18.5 kg/m^(2),smoking,drinking,no outdoor exercise and previous fracture history in the observation group was significantly higher than that in the control group(P<0.05);The levels of TK and TLK in the observation group were significantly higher than those in the control group,and the levels of bone mineral density and LL in the observation group were significantly lower than those in the control group(P<0.05).ROC analysis confirmed that bone mineral density,TK,TLK and LL could be used to predict of in patients with SOP,AUC were 0.716,0.882,0.863 and 0.831 respectively(mean P<0.05).Multivariate logistic regression analysis confirmed that age≥75 years old,BMI<18.5 kg/m^(2),smoking,drinking,no outdoor sports,previous history of fracture,BMD≤0.695 g/cm^(
作者
刘凯
张小军
丁涛
LIU Kai;ZHANG Xiao-jun;DING Tao(Orthopedics Department,Tongchuan People's Hospital,Tongchuan 727000)
出处
《医学临床研究》
CAS
2021年第6期834-837,842,共5页
Journal of Clinical Research
