摘要
目的探讨血液透析患者发生贫血的危险因素及处理措施。方法回顾性分析2019年1月至2020年6月在北京市密云区医院行血液透析治疗的197例患者的临床资料,根据血红蛋白水平是否低于110 g/L分为贫血组(141例)和未贫血组(56例),对两组的临床特征指标进行单因素分析,并对可能导致血液透析患者发生贫血的因素进行多因素Logistic回归分析。结果两组年龄、性别、血清铁蛋白、免疫反应性甲状旁腺激素(iPTH)、白蛋白、C反应蛋白(CRP)、肌酐水平比较,差异均有统计学意义(P<0.05);两组体质量、透析时间、尿素减速比(URR)、尿素清除量与体积的比值(Kt/V)、血清铁、转铁蛋白饱和度、钙、磷、钙磷乘积、尿酸、碱性磷酸酶、β微球蛋白、低密度脂蛋白水平比较,差异均无统计学意义(P>0.05);多因素Logistic回归分析结果显示,高龄、性别、白蛋白、血清铁蛋白水平较低及肌酐、iPTH、CRP水平较高是导致血液透析患者发生贫血的独立危险因素(P<0.05)。结论年龄、性别及血清铁蛋白、白蛋白、肌酐、iPTH、CRP水平是血液透析患者发生贫血的影响因素,临床应根据患者个性化特点采取相应的治疗措施以降低贫血发生率。
Objective To investigate the risk factors and treatment measures of anemia in hemodialysis patients.Methods Retrospective analysis in January 2019 to June 2020 in Beijing miyun district hospital,197 cases of hemodialysis patients clinical data,according to the patient if hemoglobin values greater than 110 g/L divided into the standard group(n=141)and not done group(n=56),clinical features in patients with two groups of index in single factor analysis,and may lead to the influence factors of anemia occurred in patients receiving hemodialysis multiariable Logistic regression analysis.Results There were significant differences in age,gender,serum ferritin,immunoreactive parathyroid hormone(iPTH),albumin,C-reactive protein(CRP)and creatinine levels between the two groups(P<0.05).There were no significant differences in body weight,dialysis time,urea reduction ratio(URR),ratio of urea clearance to volume(KT/V),serum iron and transferrin saturation,calcium,phosphorus,product of calcium and phosphorus,uric acid,alkaline phosphatase,β-microglobulin and low-density lipoprotein levels between the two groups(P>0.05).Multivariate Logistic regression analysis showed that elderly age,gender and female,lower levels of albumin and serum ferritin,and higher levels of creatinine,iPTH and CRP were independent risk factors for anemia in hemodialysis patients(P<0.05).Conclusion Age,gender and serum ferritin,albumin,creatinine,iPTH and CRP levels are the influencing factors for anemia in hemodialysis patients,and corresponding treatment measures should be taken according to the individual characteristics of patients in clinical practice to reduce the incidence of anemia.
作者
贺立娟
李晶晶
HE Lijuan;LI Jingjing(Department of Nephrology,Beijing Miyun District Hospital,Beijing 101500,China)
出处
《医疗装备》
2021年第12期6-7,10,共3页
Medical Equipment
关键词
血液透析
贫血
危险因素
处理措施
Hemodialysis
Anemia
Risk factors
Treatment measures
