摘要
目的探讨抑郁症患者采用高频重复经颅磁刺激对尼古丁渴求度的影响。方法选取2018年1月—2020年1月赣州市第三人民医院精神科收治的90例抑郁症患者的资料进行回顾性分析,按照治疗方法不同将其分为对照组与研究组,每组各45例。对照组患者采用常规药物治疗,而研究组患者则在药物治疗基础上给予高频重复经颅刺激治疗。采用尼古丁依赖检验量表(FTND)对患者治疗前后尼古丁渴求度进行评估,采用汉密尔顿抑郁量表(HAMD)评价患者的治疗效果,同时比较观察两组患者治疗前后神经递质水平变化情况。结果对照组患者治疗前后的FTND评分比较,差异无统计学意义(P>0.05);研究组患者治疗后的FTND评分低于治疗前,且低于对照组,差异有统计学意义(P<0.05)。研究组患者治疗后的HAMD评分低于对照组,血清5-羟色胺(5-HT)、多巴胺(DA)、γ-氨基丁酸(GABA)水平均高于对照组,差异有统计学意义(P<0.05)。结论高频重复经颅磁刺激在抑郁症患者治疗中,能够有效调节其神经元功能,在减轻患者对尼古丁渴求度的同时,促进临床疗效提升。
Objective To investigate the effect of high-frequency repetitive transcranial magnetic stimulation on nicotine craving in patients with depression.Methods Retrospective analysis was conducted on the data of 90 patients with depression admitted to Department of Psychiatry,the Third People's Hospital of Ganzhou from January 2018 to January 2020.The patients were grouped according to different treatment methods and divided into the control group and the study group,with 45 cases in each group.The control group received conventional drug therapy,while the study group received high-frequency repetitive transcranial stimulation on the basis of drug therapy.The Fagerstrom test of nicotine dependence(FTND)was used to evaluate the nicotine craving before and after treatment,and the Hamilton depression scale(HAMD)was used to evaluate the treatment effect.Meanwhile,the changes of neurotransmitter levels before and after treatment were compared and observed in the two groups.Results There was no statistically significant difference in FTND score in the control group before and after treatment(P>0.05).The FTND score in the study group after treatment was lower than that before treatment,and lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,the HAMD score of the study group was lower than that of the control group,while the serum levels of 5-hydroxytryptophan(5-HT),dopamine(DA)and gamma-aminobutyric acid(GABA)were higher than those of the control group the differences were statistically significant(P<0.05).Conclusion In the treatment of patients with depression,high-frequency transcranial magnetic stimulation can effectively regulate the function of neurons,reduce the patients'nicotine craving,and promote the improvement of clinical efficacy.
作者
温淑媛
廖娟萍
李海燕
李素芳
邓红冬
WEN Shu-yuan;LIAO Juan-ping;LI Hai-yan;LI Su-fang;DENG Hong-dong(Department of Psychiatry,the Third People's Hospital of Ganzhou,Jiangxi Province,Ganzhou341000,China)
出处
《中国当代医药》
CAS
2021年第19期116-119,共4页
China Modern Medicine
基金
江西省赣州市指导性科技计划项目(GZ2019ZSF213)。
关键词
高频重复经颅磁刺激
抑郁症
尼古丁渴求度
汉密尔顿抑郁量表评分
神经递质水平
High-frequency repetitive transcranial magnetic stimulation
Depression
Nicotine craving
Hamilton depression scale score
Neurotransmitter levels
