摘要
目的分析玻璃体腔注射抗血管内皮生长因子(VEGF)药物对糖尿病性黄斑水肿患者眼部血流动力学的影响效果。方法择取2018年2月—2020年10月期间该院就诊的糖尿病性黄斑水肿患者130例,经随机原则分成对照组及观察组,每组65例,对照组通过激光光凝方案进行治疗,观察组利用激光光凝+玻璃体腔注射抗VEGF药物进行治疗,分析组间治疗效果差异。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组治疗后7、28 d的黄斑中心厚度(CRT)、黄斑总体积(TMV)均低于治疗前3 d,差异有统计学意义(P<0.05),且治疗后7 d均以观察组更低,差异有统计学意义(P<0.05);观察组治疗后眼动脉(OA)的收缩期峰速(PSV)高于对照组,差异有统计学意义(P<0.05),脉动指数(PI)、阻力指数(RI)指标均低于对照组,差异有统计学意义(P<0.05);观察组治疗后视网膜中央动脉(CRA)的PSV、PI高于对照组及治疗前,差异有统计学意义(P<0.05),RI低于对照组及治疗前,差异有统计学意义(P<0.05);观察组治疗后不良反应总发生率与对照组间差异无统计学意义(P>0.05)。结论玻璃体腔注射抗VEGF药物对糖尿病性黄斑水肿患者眼部血流动力学能够产生积极影响。
Objective To analyze the effect of intravitreal injection of anti-vascular endothelial growth factor(VEGF)drugs on ocular hemodynamics in patients with diabetic macular edema.Methods 130 patients with diabetic macular edema who were treated in the hospital from February 2018 to October 2020 were selected.They were randomly divided into a control group and an observation group,with 65 cases in each group.The control group was treated by laser photocoagulation,the observation group was treated with laser photocoagulation+intravitreal injection of anti-VEGF drugs,and the difference in treatment effect between the groups was analyzed.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05);the macular center thickness and total macular volume of the two groups were lower than that of the 3 d before treatment on the 7th and 28th day after treatment,and the difference was statistically significant(P<0.05),and the observation group was lower on the 7th day after treatment,and the difference was statistically significant(P<0.05);after treatment,the peak systolic velocity(PSV)of the ophthalmic artery(OA)of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05),and the pulsation index(PI)and resistance index(RI)indexes were lower than those of the control group,the difference was statistically significant(P<0.05);the PSV and PI of the central retinal artery(CRA)of the observation group after treatment were higher than those of the control group and before treatment,the difference was statistically significant(P<0.05),RI was lower than control group and before treatment,and the difference was statistically significant(P<0.05);the total incidence of adverse reactions after treatment in the observation group was not statistically significanty different from that in the control group(P>0.05).Conclusion Intravitreal injection of anti-VEGF drugs can hav
作者
侯立强
HOU Liqiang(Department of Drug Dispatching,Zibo Central Hospital,Zibo,Shandong Province,255036 China)
出处
《糖尿病新世界》
2021年第9期5-8,共4页
Diabetes New World Magazine
