摘要
目的探讨对咳嗽变异性哮喘患者联合加味半夏厚朴汤治疗后的临床效果。方法简单随机选取该院2017年6月—2020年4月门诊及住院收治的100例咳嗽变异性哮喘患者,按照数字奇偶法分组;对照组(50例):采用吸入糖皮质激素+支气管扩张剂完成咳嗽变异性哮喘治疗;治疗组(50例):在对照组基础上联合加味半夏厚朴汤治疗;就组间咳嗽变异性哮喘总治疗有效率、中医症状积分、外周血嗜酸性粒细胞(eosinophil,EOS)、白细胞介素-6(interleukin-6,IL-6)、咳嗽症状改善时间展开对比。结果治疗组咳嗽变异性哮喘患者总治疗有效率(98.00%)高于对照组(84.00%),差异有统计学意义(χ^(2)=4.395,P<0.05);治疗前,治疗组咳嗽变异性哮喘患者中医症状积分(14.99±4.32)分、EOS(0.46±0.80)×10^(9)/L以及IL-6(89.02±23.02)IU/mL同对照组中医症状积分(15.03±3.51)分、EOS(0.47±0.81)×10^(9)/L以及IL-6(90.15±25.05)IU/mL比较差异无统计学意义(t=0.050、0.062、0.234,P>0.05);治疗后,治疗组中医症状(3.42±1.72)分、EOS(0.25±0.06)×10^(9)/L以及IL-6(37.51±7.41)IU/mL均低于对照组中医症状(7.52±2.23)分、EOS(0.36±0.08)×10^(9)/L以及IL-6(56.11±15.62)IU/mL,差异有统计学意义(t=10.294、7.778、7.607,P<0.05);治疗组咳嗽变异性哮喘患者夜咳停止时间(56.11±15.62)d、咳嗽消退时间(11.52±4.42)d以及咳嗽缓解时间(5.02±1.42)d均短于对照组夜咳停止时间(10.42±3.32)d、咳嗽消退时间(15.62±3.31)d以及咳嗽缓解时间(9.62±3.02)d,差异有统计学意义(t=7.960、5.250、9.746,P<0.05)。结论临床针对咳嗽变异性哮喘患者联合加味半夏厚朴汤治疗,可使总体疗效增强,中医症状积分、EOS、IL-6显著降低,咳嗽症状改善时间明显缩短。
Objective To investigate the clinical effect of combined treatment with Banxia Houpu Decoction in patients with cough variant asthma.Methods Simple random select 100 cases of cough variant asthma patients admitted to the hospital from June 2017 to April 2020 were divided into groups according to the digital parity method;control group(50 cases):inhaled corticosteroids+bronchodilators were used to complete the cough mutation treatment of asthma;treatment group(50 cases):combined with Banxia Houpu decoction on the basis of the control group;the total effective rate of treatment of cough variant asthma,TCM symptom score,eosinophi l(EOS),interleukin-6(IL-6),cough symptom improvement time were compared.Results The total effective rate of treatment for patients with cough variant asthma in the treatment group(98.00%)was higher than that of the control group(84.00%),and the difference was statistically significant(χ^(2)=4.395,P<0.05);before treatment,the TCM symptom score of patients with cough variant asthma in the treatment group(14.99±4.32)points,EOS(0.46±0.80)×10^(9)/L and IL-6(89.02±23.02)IU/mL were the same as the control group TCM symptom score(15.03±3.51)points,EOS(0.47±0.81)×10^(9)/L and IL-6(90.15±25.05)IU/mL was not statistically significantly different(t=0.050,0.062,0.234,P>0.05);after treatment,TCM symptoms(3.42±1.72)points,EOS(0.25±0.06)×10^(9)/L and IL-6(37.51±7.41)IU/mL in the treatment group were lower than the control group of TCM symptom(7.52±2.23)score,EOS(0.36±0.08)×10^(9)/L and IL-6(56.11±15.62)IU/mL,and the difference was statistically significant(t=10.294,7.778,7.607,P<0.05);in the treatment group cough variant asthma patients stopped time of night cough(6.41±1.29)d,cough subsided time(11.52±4.42)d,and cough relief time(5.02±1.42)d were shorter than the control group’s night cough stopping time(10.42±3.32)d,cough resolution time(15.62±3.31)d,and cough relief time(9.62±3.02)d,and the difference was statistically significant(t=7.960,5.250,9.746,P<0.05).Conclusion The clinic
作者
诸晶
ZHU Jing(Department of Pulmonology,Quanzhou Hospital of Traditional Chinese Medicine,Quanzhou,Fujian Province,362000 China)
出处
《中外医疗》
2021年第14期169-171,共3页
China & Foreign Medical Treatment
