摘要
目的研究猕猴桃果实及全株防治动脉粥样硬化(AS)活性,扩大其药用价值。方法利用高脂血家兔模型,分析猕猴桃果实和全株提取物干预后血液流变学、血脂五项和血浆中超氧化物歧化酶(SOD)等生化指标变化以及观察主动脉弓病理形态的差别评价猕猴桃果实和全株提取物体内预防动脉粥样硬化药效。结果实验结束时与正常组相比,模型组体重、大部分血脂指标及血液流变学指标明显升高,差异有统计学意义(P<0.05),SOD差异无统计学意义(P>0.05);实验结束时果实组与正常组和模型组相比SOD明显升高,差异有统计意义(P<0.05),果实组和全株组大部分血脂指标与模型组和正常组之间差异具有统计学意义(P<0.05),全株组大部分血液流变学指标升高程度也低于模型组且差异有统计意义(P<0.05);果实组主动脉弓病变程度低于模型组,全株组主动脉弓病变很小。结论猕猴桃全株和果实的乙醇-水提取物都具有一定的降血脂和改善血液流变学药效,从而一定程度上能预防因高脂饮食而导致的早期动脉粥样硬化病变。
Objective To study the anti-atherosclerosis(AS)activity of kiwi fruit and its whole plant and to expand its medicinal value.Methods We analyzed the changes of biochemical indexes including hemorheology,blood lipids,superoxide dismutase(SOD)in the plasma of the rabbit model with hyperlipidemia.After the intervention of kiwi fruit and its whole plant extract,we observed the difference in pathological morphology of aortic arch,so as to evaluate the effect of kiwi fruit and the whole plant extract on preventing atherosclerosis in vivo.Results At the end of the experiment,in comparison with the normal group,the model group had significantly increased indexes including body weight,most of the blood lipid indexes and hemorheology indexes,with statistically significant differences(P<0.05),while there was no significant difference in SOD between these two groups(P>0.05).At the end of the experiment,the SOD in the fruit group was significantly higher than that in the normal group and that of the model group,and the difference was statistically significant(P<0.05).Most of lipid indexes of the fruit group and the whole plant group were significantly different from those of the model group and those of the normal group(P<0.05).Most of the hemorheological indexes in the whole plant group increased less than that in the model group,and the differences were statistically significant(P<0.05).The lesion in aortic arch of the fruit group was slighter than that in the model group,and the lesion in aortic arch of the whole plant group was very small.Conclusion The ethanol-water extracts of kiwi fruit and the whole plant have certain effect of lowering blood lipid and improving hemorheology,thus preventing early atherosclerosis caused by high fat diet to a certain extent.
作者
王豪
黄永毅
李保生
元辉雄
莫丽娟
庞金凤
李晴红
卢顺
杨彩艳
Wang Hao;Huang Yongyi;Li Baosheng;Yuan Huixiong;Mo Lijuan;Pang Jinfeng;Li Qinghong;Lu Shun;Yang Caiyan(Jiangsu Provincial Key Laboratory of Biological Manufacturing of Chiral Pharmaceutical Chemicals,Taizhou University,Taizhou 225300,Jiangsu,China;Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;People’s Hospital of Donglan,Hechi 547400,Guangxi,China)
出处
《右江民族医学院学报》
2021年第3期314-318,共5页
Journal of Youjiang Medical University for Nationalities
基金
广西自然科学基金面上项目(2020GXNSFAA159079)
右江民族医学院高层次人才科研项目(RZ2100000546)
右江民族医学院广西高校重点实验室开放课题(kfkt2017007)。
