摘要
目的:应用网状Meta分析的方法,评价西格列汀、维格列汀、沙格列汀、利格列汀和阿格列汀治疗2型糖尿病的疗效。方法:检索CNKI知网、万方数据、维普咨讯和PubMed、EMBASE、Cochrane Library等数据库,进行文献筛选和质量评价,提取数据并使用Stata15.1软件与R软件进行数据处理和统计分析,对西格列汀、维格列汀、沙格列汀、利格列汀和阿格列汀治疗2型糖尿病的疗效进行比较。结果:共纳入40篇文献,包含40个随机对照试验、9266名受试者。网状Meta分析结果显示,降低糖化血红蛋白的疗效,阿格列汀>维格列汀50 mg bid>西格列汀>沙格列汀>利格列汀>维格列汀50 mg qd;降低空腹血糖的疗效,阿格列汀>西格列汀>沙格列汀>维格列汀50 mg bid>利格列汀>维格列汀50 mg qd。结论:5种药物治疗2型糖尿病的疗效,阿格列汀最好,维格列汀50 mg bid、西格列汀、沙格列汀、利格列汀疗效居中,维格列汀50 mg qd相对较差。
Objective:The network meta-analysis approach was applied to review the efficacy of sitagliptin,vildagliptin,saxagliptin,linagliptin and alogliptin in the treatment of type 2 diabetes mellitus.Methods:Databases including CNKI,Wanfang VIP and PubMed,EMBASE,Cochrane Library were searched.The literature was screened and the quality of the screened literature was evaluated.Then the data were extracted and Stata 15.1 software with R software was used for data processing and statistical analysis.The efficacy of sitagliptin,vildagliptin,saxagliptin,linagliptin and alogliptin in the treatment of type 2 diabetes mellitus was compared.Results:A total of 40 randomized controlled trials involving 9266 subjects were included.The results of network Meta-analysis showed that the efficacy of reducing HbA1c was:alogliptin>vildagliptin 50 mg bid>sitagliptin>saxagliptin>linagliptin>vildagliptin 50 mg qd.The efficacy of reducing FPG was:alogliptin>sitagliptin>saxagliptin>vildagliptin 50mg bid>linagliptin>vildagliptin 50 mg qd.Conclusions:Among the five drugs in the treatment of type 2 diabetes mellitus,the effect of alogliptin is the best,the effect of vildagliptin 50mg bid,sitagliptin,saxagliptin and linagliptin is in the middle,and the effect of vildagliptin 50 mg qd is relatively poor.
作者
王雪
孙冠男
田会景
高媛
贾媛媛
颜久兴
袁恒杰
WANG Xue;SUN Guan-Nan;TIAN Hui-Jing;GAO Yuan;JIA Yuan-Yuan;YAN Jiu-Xing;YUAN Heng-Jie(Tianjin Medical University Pharmacy College,Tianjin 300070,China;Tianjin Vocational College of Bioengineering,Tianjin 300462,China;Tianjin Medical University General Hospital,Tianjin 300070,China)
出处
《中国药物评价》
2021年第3期235-244,共10页
Chinese Journal of Drug Evaluation
关键词
二肽基肽酶4抑制剂
2型糖尿病
疗效
网状Meta分析
Dipeptidyl peptidase 4 inhibitor
Type 2 diabetes mellitus
Efficacy
Network Meta-analysis
