摘要
癌症是目前全球范围内引起死亡的主要疾病之一,受到人们的高度重视。然而传统的癌症治疗方法仍存在许多缺陷,严重影响了癌症治疗效果并给患者带来了许多不利影响。随着纳米材料的发展,光动力疗法(PDT)和光热疗法(PTT)等新型治疗方法有效弥补了传统治疗方法的不足。其中,将不同成分的纳米半导体材料组合成一个纳米结构的异质结在光动力疗法和光热疗法上有着优异的表现。异质结材料因其特有光学特性和结构设计性,在催化、检测、多模态成像和肿瘤的协同治疗领域中有很大的应用潜力。本文根据结构分类对不同种类异质结的原理进行了大致介绍,并对近年来异质结材料在肿瘤的单重治疗、协同治疗与诊疗一体化中的研究进展进行了系统性的综述,最后对异质结材料在癌症诊断治疗领域的未来发展方向进行了展望。
At present, cancer is one of the major fatal diseases worldwide, and traditional treatment methods have many drawbacks. New therapeutic methods such as photodynamic therapy(PDT) and photothermal therapy(PTT)have effectively made up for the deficiency of traditional therapeutic methods with the development of nanomaterials. Heterojunction which combines nanomaterials of different compositions into a nanostructure exhibits an excellent performance in photodynamic therapy and photothermal therapy. Heterojunction materials have great application potential in the fields of catalysis, detection, multi-modal imaging and collaborative treatment of tumors due to their inherent peculiarities, including magnetic properties, optical properties and structural design. This article systematically reviews the recent progress of heterojunction materials in single tumor therapy, cooperative therapy and the integration of diagnosis and treatment, and the future development direction of heterojunction materials is also prospected.
作者
毛誉蓉
赵建魁
周雄
杨为中
邓怡
MAO Yurong;ZHAO Jiankui;ZHOU Xiong;YANG Weizhong;DENG Yi(College of Biomedical Engineering,Sichuan University,Chengdu 610065,China;School of Chemical Engineering,Sichuan University,Chengdu 610065,China)
出处
《复合材料学报》
EI
CAS
CSCD
北大核心
2021年第6期1703-1723,共21页
Acta Materiae Compositae Sinica
基金
国家自然科学基金青年科学基金项目(81801848)
国家自然科学基金委员会与香港研究资助局联合科研资助基金(81961160736)
中科协青年人才托举工程
四川大学-泸州市人民政府战略合作项目(2020CDLZ-5)。
关键词
异质结
肿瘤治疗
光热治疗
协同治疗
多模态成像
heterojunction
tumor therapy
photothermal therapy
synergistic therapy
multimodal imaging
