摘要
目的分析予以术后分化型甲状腺癌患者促甲状腺激素(TSH)抑制治疗的疗效和安全性。方法2014年1月—2016年12月采用整群抽样法本院收治的分化型甲状腺癌共1512例患者进行研究,依据随机数表法将其中756例纳入对照组(甲状腺激素替代治疗),余下756例纳入观察组(TSH抑制治疗),统计并比较两组术后1年及3年的复发率、转移率和不良反应情况。结果观察组术后1年及3年的复发率、远处转移率及颈部淋巴结转移率均低于对照组,发热、皮疹、震颤、骨质疏松以及心率异常等不良反应出现少于对照组(P<0.05)。结论术后予以分化型甲状腺癌患者TSH抑制治疗效果显著,能减少其转移和复发,且安全性较高。
Objective To analyze the effects and safety of thyroid-stimulating hormone(TSH)suppression therapy in differentiated thyroid carcinoma.Methods Through cluster sampling method,1512 patients with differentiated thyroid carcinoma treated from January 2014 to December 2016 in our hospital were investigated and randomly assigned to control group(756 cases)and observation group(756 cases).The control group adopted thyroid hormone replacement therapy;the observation group adopted TSH suppression therapy.After 1y to 3y of surgery,the recurrence rate,metastasis rate and adverse reactions were counted.Results After 1y to 3y of surgery,the recurrence rate,distant metastasis rate and cervical lymph node metastasis rate in the observation group were lower than control group;the incidences of adverse reactions like fever,skin rash,tremor,osteoporosis and abnormal heart rate in the observation group were lower than control group (P<0.05). Conclusion TSH suppression therapy has obvious effects in differentiated thyroid carcinoma patients, which can reduce the metastasis and recurrence rate, and increase the treatment safety.
作者
沈依
李小恩
陈舟侃
SHEN Yi;LI Xiaoen;CHEN Zhoukan(Department of General Surgery,Luwan Branch of Ruijin Hospital Affiliated to Medical College of Shanghai Jiaotong University,Shanghai 200020,China)
出处
《中国继续医学教育》
2021年第20期170-173,共4页
China Continuing Medical Education
关键词
甲状腺癌
甲状腺切除术
抑制治疗
促甲状腺激素
复发率
远处转移率
不良反应
thyroid carcinoma
thyroidectomy
suppression therapy
thyroid-stimulating hormone
recurrence rate
distant metastasis rate
adverse reactions
