摘要
目的探讨彩色多普勒超声联合肝动脉相关指数预测老年原发性肝癌(PLC)介入化疗疗效及预后的价值。方法回顾性分析2017年3月~2018年12月本院收治的236例老年(>60岁)PLC患者的临床资料。统计老年PLC患者治疗情况;对比无效组和有效组患者的临床资料;Logistic回归分析影响老年PLC患者TACE治疗效果的因素;制作受试者工作特征曲线(ROC),分析肝动脉相关指数对老年PLC患者治疗效果的预测价值;术后随访1年,肝动脉相关指数分析老年PLC患者预后情况。结果本研究老年PLC患者经TACE治疗后,治疗无效发生率为24.58%。Logistic回归分析结果显示,病理分型为低分化、肝动脉收缩期峰值(PSV)及肝动脉搏动指数(PI)均为影响老年PLC患者TACE治疗效果的因素(OR=4.011、3.340、2.807,P<0.05)。ROC分析显示,PSV、PI预测老年PLC患者治疗无效的最佳截断点分别为82.42 cm/s、1.73,曲线下面积值分别为0.772、0.753。预后不良组PSV、PI均显著高于预后不良组(P<0.05)。结论彩色多普勒超声联合PSV、PI预测老年PLC介入化疗疗效及预后效能较高,可作为评估疗效及预后的重要指标。
Objective To explore the value of color Doppler ultrasound combined with hepatic artery related index in predicting the efficacy and prognosis of interventional chemotherapy for elderly patients with primary liver cancer(PLC).Methods The clinical data of 236 elderly patients with PLC admitted to our hospital from March 2017 to December 2018 were retrospectively analyzed.Statistics of elderly patients with PLC were analyzed.The clinical data of patients in the invalid group and the effective group were compared.Logistic regression analysis was used to analyze the factors of TACE treatment in elderly patients with PLC.ROC was used to analyze the predictive value of hepatic artery correlation index for the treatment effect of elderly patients with PLC.After 1 year follow-up,the hepatic artery related index was used to analyze the prognosis of elderly patients with PLC.Results The incidence of treatment failure in elderly PLC patients was 24.58%after TACE treatment.The pathological classification was poorly differentiated.Peak hepatic artery systole(PSV)and Hepatic artery pulsation index(PI)were all factors affecting the treatment effect of TACE in elderly patients with PLC(OR=4.011,3.340,2.807,all P<0.05).ROC analysis showed that the best cut-off points for PSV and PI to predict treatment failure in elderly PLC patients were 82.42 cm/s and 1.73,respectively.The AUC values were 0.772 and 0.753,respectively.The PSV and PI of the poor prognosis group were significantly higher than those of the poor prognosis group(P<0.05).Conclusion Color doppler ultrasound combined with PSV and PI has a higher efficacy in predicting the efficacy and prognosis of PLC interventional chemotherapy in the elderly.It can be used as an important indicator for evaluating the efficacy and prognosis.
作者
徐瑞
刘欣
XU Rui;LIU Xin(Department of Internal Cardiovascular,The Second Affiliated Hospital of Army Military Medical University,Chongqing 400037,China;Department of Medical Imaging,Hubei Provincial Armed Police Corps Hospital,Wuhan 430061,China)
出处
《分子影像学杂志》
2021年第3期521-525,共5页
Journal of Molecular Imaging
关键词
老年
原发性肝癌
彩色多普勒超声
肝动脉指数
化疗
预后
elderly
primary liver cancer
color Doppler ultrasound
hepatic artery index
chemotherapy
prognosis
