摘要
恶性肿瘤是危害人类健康的一大难题,转移是导致恶性肿瘤具有难治性和致死性的关键因素。Artemin(ARTN)是胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)配体家族(GDNF-family ligands,GFLs)中的一员,其信号转导主要通过与共受体GFRα3-RET结合,形成一个信号复合物调节细胞内信号转导,影响神经系统发育和细胞内稳态。近年来,多项研究表明Artemin在呼吸系统肿瘤、消化系统肿瘤等多种恶性肿瘤中具有促进肿瘤细胞侵袭和转移的作用,与肿瘤的复发转移及预后密切相关。
Malignant tumor has become a serious problem that threatens human health,and tumor metastasis is one of the key factors leading to disease obstinacy and death.Artemin(ARTN)is a member of the glial cell linederived neurotrophic factor(GDNF)family of ligands(GFLs),and the signaling transduction is mainly through the combination with the co-receptor GFRα3-RET to form a signal complex that regulates intracellular signal transduction and affect the development of the nervous system and cell homeostasis.In recent years,a number of studies have shown that Artemin can promote the invasion and metastasis of tumor cells in a variety of malignant tumors such as respiratory system tumors and digestive system tumors,and is closely related to tumor recurrence,metastasis and prognosis.
作者
朱梦景(综述)
周怀君(审校)
ZHU Mengjing;ZHOU Huaijun(Department of Gynecology,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210008,China)
出处
《临床与病理杂志》
CAS
2021年第6期1382-1387,共6页
Journal of Clinical and Pathological Research
基金
国家自然科学基金(81972434)。
