摘要
目的探讨糖尿病前期人群脂肪肝发病危险因素,为后期健康指导提供参考依据。方法选取2019年4-8月在华东疗养院健康体检中心进行健康体检的糖尿病前期人群作为研究对象,其中322例脂肪肝患者为病例组,219例非脂肪肝患者为对照组。比较两组基础资料、生活习惯及血生化相关指标的组间差异,通过单因素及多因素Logistic回归分析筛选糖尿病前期人群脂肪肝发病危险因素。结果病例组吸烟史、运动频率、饮食特点及体质量指数(BMI)、超重或肥胖比例、三酰甘油(TG)、高密度脂蛋白胆固醇、丙氨酸氨基转移酶及天门冬氨酸氨基转移酶、空腹血糖水平与对照组比较,差异均有统计学意义(P<0.05);单因素与多因素Logistic结果均显示,吸烟史、偶尔或从不运动、荤食、超重或肥胖、TG水平异常是糖尿病前期人群脂肪肝发病的独立危险因素(P<0.05),而超重或肥胖人群与TG水平异常人群出现脂肪肝的风险分别是BMI正常人群的2.148倍及2.108倍。结论经常吸烟、运动量较少、荤食为主、体质量过高及TG水平异常是糖尿病前期人群形成脂肪肝的危险因素,对于超重或肥胖及TG水平异常人群应重点进行早期健康指导及治疗,以降低脂肪肝的发病率。
Objective To explore the risk factors of fatty liver disease in patients with pre-diabetes and to provide reference for health guidance in the future.Methods From April to August 2019,pre-diabetic patients who underwent physical examination in Health Examination Center of East China Sanatorium were selected as research subjects,among which 322 patients with fatty liver were included in the case group and 219 patients with non-fatty liver were included in the control group.The differences between the two groups in basic data,living habits and blood biochemical related indicators were compared,and the risk factors of fatty liver in prediabetic population were screened by univariate and multivariate Logistic regression analysis.Results There were statistically significant differences between the case group and the control group in smoking history,exercise frequency,dietary characteristics,body mass index(BMI),proportion of overweight or obesity,triglyceride(TG),high-density lipoprotein cholesterol,alanine aminotransferase and aspartate aminotransferase,fasting blood glucose levels(P<0.05).Univariate and multivariate Logistic regression analysis showed that,smoking history,exercise occasionally or never,non-vegetarian meals,overweight or obesity,triglycerides are independent risk factors for fatty liver disease in pre-diabetes(P<0.05),while probability of suffering fatty liver in populations with overweight or obese and abnormal triglyceride is 2.148 times and 2.108 times than those with normal BMI.Conclusion Frequent smoking,less exercise,meat-based diet,excessive body weight and abnormal triglycerides are risk factors for the formation of fatty liver in people with pre-diabetes.Early health guidance and treatment should be focused on the population of overweight or obese and abnormal triglycerides in order to reduce the incidence of fatty liver.
作者
卢亚运
方勇
顾娅萍
许智越
LU Yayun;FANG Yong;GU Yaping;XU Zhiyue(Health Examination Center,East China Sanatorium,Wuxi,Jiangsu 214065,China;Department of Laboratory Medicine,East China Sanatorium,Wuxi,Jiangsu 214065,China)
出处
《国际检验医学杂志》
CAS
2021年第13期1598-1601,1605,共5页
International Journal of Laboratory Medicine
基金
2018年上海市“医苑新星”青年医学人才培养资助计划[(2019)72]。
