摘要
目的研究NAFLD合并IR患者外周血CD4^(+)CD25^(+)Treg细胞的功能特征。方法将医院2017年1月至2019年12月间收治的30例NAFLD合并IR患者(①组)、30例单纯NAFLD患者(②组)及20例健康志愿者(③组)纳为研究对象,检测并比较三组外周血CD4^(+)CD25^(+)Treg水平,同时以①组患者HOMA-IR平均值为划分界限,将其分为高IR组及低IR组,比较两组外周血CD4^(+)CD25^(+)Treg水平。结果①组与②组AST、ALT、TC、TG水平均无显著性差异(P>0.05),两组以上指标水平均显著高于③组(P<0.05),①组HOMA-IR水平显著高于②组(P<0.05),两组均显著高于③组(P<0.05);①组外周血CD4^(+)CD25^(+)Treg水平显著低于②组(P<0.05),且两者CD4^(+)CD25^(+)Treg水平均显著低于③组(P<0.05);高IR组CD4^(+)CD25^(+)Treg水平显著低于低IR组(P<0.05)。结论NAFLD患者外周血CD4^(+)CD25^(+)Treg数量下降,免疫功能异常,而IR将加重CD4^(+)CD25^(+)Treg数量的减少,调整患者生活习惯,缓解IR,在NAFLD患者病情中具有积极意义。
Objective To investigate the functional characteristics of CD4^(+)CD25^(+)regulatory T cells(Treg)in peripheral blood of insulin resistance(IR)patients with nonalcoholic fatty liver disease(NAFLD).Methods 30 cases of NAFLD combined with IR(group①),30 cases of NAFLD(group②)and 20 healthy individuals(group③)in our hospital from January 2017 to December 2019 were enrolled.Routine laboratory indexes,HOMA-IR levels and peripheral blood CD4^(+)CD25^(+)Treg levels were detected.According to the average value of HOMA-IR in group①,they were further divided into high IR group and low IR group,and the levels of CD4^(+)CD25^(+)Treg in peripheral blood of the two groups were compared.Results AST,ALT,TC,TG levels of group①and group②had no significant difference(P>0.05),while were higher than those of group③(P<0.05).Among three groups,HOMA-IR level was the highest in group①,followed by group②and group③(P<0.05),meanwhile,the CD4^(+)CD25^(+)Treg level was the lowest in group①,followed by group②and group③(P<0.05).CD4^(+)CD25^(+)Treg level in high IR group was significantly lower than that in the low IR group(P<0.05).Conclusion The number of CD4^(+)CD25^(+)Treg in peripheral blood of NAFLD patients is decreased and the immune function is abnormal,while IR will aggravate the reduction of CD4^(+)CD25^(+)Treg,so it is of positive significance to adjust the living habits of patients to alleviate IR in patients with NAFLD.
作者
吕晓玉
王中京
LV Xiao-yu;WANG Zhong-jing(Department of Endocrinology,Wuhan Central Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Hubei 430014,China)
出处
《肝脏》
2021年第6期667-669,共3页
Chinese Hepatology
基金
2017年湖北省卫计委科研项目(WJ2017M183)。
