摘要
目的探讨静脉应用白蛋白对慢性失代偿性心力衰竭合并低蛋白血症患者再住院及预后的影响。方法79例慢性失代偿性心力衰竭合并低蛋白血症患者,其中48例静脉应用白蛋白(作为治疗组),31例未静脉应用白蛋白(作为对照组)。比较两组患者入院时的基线指标,出院时的相关指标,出院后的随访时间、再住院次数、死亡情况。结果两组患者入院时的基线指标比较,差异无统计学意义(P>0.05)。治疗组患者出院时的白蛋白高于对照组,谷丙转氨酶、N末端B型利钠肽前体(NT-proBNP)低于对照组,谷丙转氨酶恢复正常时间、住院时间短于对照组,静脉应用呋塞米总量少于对照组,差异具有统计学意义(P<0.05)。两组患者出院时的肌酐比较,差异无统计学意义(P>0.05)。治疗组患者出院后的再住院次数[7(6,9)]次少于对照组的[8(6,9)]次、死亡率14.58%低于对照组的35.48%,差异具有统计学意义(P<0.05)。两组患者出院后的随访时间比较,差异无统计学意义(P>0.05)。结论慢性失代偿性心力衰竭合并低蛋白血症患者静脉应用白蛋白可以缩短住院时间,减少呋塞米应用总量,降低患者出院后再住院及死亡情况。
Objective To discuss the effect of albumin on rehospitalization and prognosis in patients with chronic decompensated heart failure and hypoproteinemia.Methods A total of 79 patients with chronic decompensated heart failure and hypoproteinemia,of which 48 patients were treated with albumin intravenously(as the treatment group),31 patients were not treated with albumin intravenously(as the control group).The baseline indicators at admission,related indicators at discharge,follow-up time after discharge,number of rehospitalizations,and deaths were compared between the two groups.Results There was no statistically significant difference in baseline indicators at admission between the two groups(P>0.05).The albumin at discharge of the treatment group was higher than that of the control group,glutamic-pyruvic transaminase,N-terminal pro-brain natriuretic peptide(NT-proBNP)were lower than those of the control group,glutamic-pyruvic transaminase return to normal time and hospitalization time were shorter than those of the control group,and total furosemide intravenously was less than that of the control group.All the difference was statistically significant(P<0.05).There was no statistically significant difference in creatinine at discharge between the two groups(P>0.05).The number of rehospitalizations[7(6,9)]times of the treatment group was less than[8(6,9)]times of the control group,and death rate 14.58%was lower than 35.48%of the control group.All the difference was statistically significant(P<0.05).There was no statistically significant difference in follow-up time after discharge between the two groups(P>0.05).Conclusion Intravenous administration of albumin in patients with chronic decompensated heart failure and hypoalbuminemia can shorten the hospitalization time,reduce the total amount of furosemide,and reduce the number of rehospitalizations and deaths after discharge.
作者
操斌全
汪芸
胡星星
张涵
盛洁
CAO Bin-quan;WANG Yun;HU Xing-xing(Department of Cardiology,Anhui Provincial Corps Hospital of Chinese People’s Armed Police Force,Hefei 230041,China)
出处
《中国实用医药》
2021年第18期12-15,共4页
China Practical Medicine
关键词
白蛋白
心力衰竭
呋塞米
预后
Albumin
Heart failure
Furosemide
Prognosis
