摘要
目的:采用GC法测定苯氧乙醇中的有关物质。方法:采用WM-PEG20M色谱柱(30 m×0.25 mm, 0.25μm);起始柱温:90℃,以每分钟10℃的速率升温至220℃,维持10 min;进样口温度:250℃;检测器温度:270℃;分流比1∶100。结果:主要已知杂质苯酚在0.01~2.0 mg·mL^(-1)内线性关系良好(r=0.999 8),平均回收率为105.5%,RSD为2.6%。结论:该方法专属性、精密度、重复性、耐用性好,准确可靠,能够符合苯氧乙醇中有关物质的检测要求。
Objective:To determine the related substances in 2-Phenoxyethanol by GC.Methods:The test was performed in WM-PEG20M GC column(30 m×0.25 mm,0.25μm)with the initial column temperature at 90℃,raising to 220℃at a rate of 10℃per min and maintaining 220℃for 10 min.The injection temperature was 250℃,and the detection temperature was 270℃.The split ratio was 1100.Results:The liner range of the main impurity phenol fell into 0.01-2.0 mg·mL^(-1)(r=0.9998).The average recovery was 105.5%with RSD as 2.6%.Conclusion:The established method has the good specificity,precision,reproducibility and robustness,and is accurate and reliable.That can meet the requirements for determination of the related substances in 2-Phenoxyethanol.
作者
胡淑君
叶秀金
王彩媚
陈英
HU Shujun;YE Xiujin;WANG Caimei;CHEN Ying(Guangdong Institute for Drug Control,Guangzhou 510663,China)
出处
《中国药品标准》
CAS
2021年第3期216-219,共4页
Drug Standards of China
