摘要
目的探讨抑郁症患者精神焦虑与多导睡眠图(PSG)参数相关性。方法选取2018年6月至2020年5月佛山市第三人民医院功能检查科接收的抑郁症患者68例作为研究对象,按汉密尔顿抑郁24项(Hamilton depressive 24,HAMD 24)量表第10项(HAMD-10)评分内容,以HAMD-10≥1分为研究组(n=42),HAMD-10<1分为对照组(n=26)。两组患者均行PSG图监测,比较两组PSG参数:总睡眠时间(TST)、睡眠效率(SE)、睡眠潜伏期(SL)、醒觉次数(NW)、醒觉时间(AT)、快速眼动相睡眠活动度(RA)、快速眼动相睡眠强度(RI)、非快动眼睡眠第1期(N1)、非快动眼睡眠第2期(N2)、非快动眼睡眠第3期(N3)。模型1将HAMD-10评分作为自变量,PSG参数为应变量行单因素方差分析;模型2将HAMD校正分作为中心协变量,PSG参数作为应变量行协方差分析,评估精神焦虑与PSG参数的相关性是否与抑郁严重评分有关。结果研究组的TST、SE、N3低于对照组;研究组的SL、NW、AT高于对照组,差异有统计学意义(P<0.05)。模型1分析显示,精神焦虑的抑郁症患者与SL、NW、AT及N3有关;模型2分析显示,精神焦虑的抑郁症患者与AT及N3有关,差异有统计学意义(P<0.05)。结论精神焦虑的抑郁症患者PSG参数表现为SL、NW、AT下降,TST、SE、N3延长;AT及N3与精神焦虑有相关性。
Objective To explore the correlation between mental anxiety and polysomnography parameters in patients with depression.Methods A total of 68 cases patients were diagnosed with depression from department of Functional Inspectio of the Third People's Hospital of Foshan City from June 2018 to May 2020 were selected as the research objects.Refer to the Hamilton Depression Scale Item 10(HAMD-10)score content of Hamilton Depression 24 Scale(HAMD 24),Patients were divided into the study group(HAMD-10 score≥1,n=42)and the control group(HAMD-10 score<1,n=26).Both groups of patients were monitored by polysomnography.The polysomnography parameters:Total sleep time(TST),Sleep efficiency(SE),Sleep latency(SL),Number of wakes(NW),Awake time(AT),Rapid eye movement sleep activity(RA),Rapid eye movement sleep intensity(RI),Non-rapid eye movement sleep phase 1(N1),Non-rapid movement Eye sleep stage 2(N2),Non-rapid eye movement sleep stage 3(N3)were compared.Model 1 were took the HAM-D10 score as the independent variable,Polysomnography parameters were the dependent variables for one-way ANOVA analysis of variance.Model 2 were used the HAMD correction points as the central covariate,and polysomnography parameters as the dependent variables for covariance analysis to evaluated the correlation between mental anxiety and polysomnography parameters is it related to depression severity score.Results The TST,SE,and N3 of the study group were lower than those of the control group;The SL,NW,and AT of the study group were higher than those of the control group,an d the difference were statistically significant(P<0.05).Model 1 analysis showed that mental anxiety were related to SL,NW,AT and N3;Model 2 analysis showed that mental anxiety were related to AT and N3,and the difference were statistically significant(P<0.05).Conclusion The polysomnography parameters of mental anxiety with depressive patients are decreased in SL,NW,AT,and prolonged in TST,SE,and N3;AT and N3 are correlated with men tal anxiety.
作者
丁秀珊
徐彩霞
徐国洪
DING Xiushan;XU Caixia;XU Guohong(Department of Functional Inspectio,the Third People's Hospital of Foshan City,Guangdong,Foshan 528000,China)
出处
《中国医药科学》
2021年第11期201-204,226,共5页
China Medicine And Pharmacy
基金
广东省佛山市卫生健康局医学科研课题(20200197)。
关键词
精神焦虑
抑郁症
多导睡眠图
相关性
Mental anxiety
Depression
Polysomnography
Correlation
