摘要
Most commonly used wound dressings have severe problems,such as an inability to adapt to wound shape or a lack of antibacterial capacity,affecting their ability to meet the requirements of clinical applications.Here,a nanocomposite hydrogel(XKP)is developed by introducing polydopamine nanoparticles(PDA NPs)into a food gum matrix(XK,consisting of xanthan gum and konjac glucomannan,both FDA-approved food thickening agents)for skin wound healing.In this system,the embedded PDA NPs not only interact with the food gum matrix to form a hydrogel with excellent mechanical strength,but also act as photothermal transduction agents to convert near-infrared laser radiation to heat,thereby triggering bacterial death.Moreover,the XKP hydrogel has high elasticity and tunable water content,enabling it to adapt to the shape of the wound and insulate it,providing a moist environment suitable for healing.In-vivo skin wound healing results clearly demonstrate that XKP can significantly accelerate the healing of wounds by reducing the inflammatory response and promoting vascular reconstruction.In summary,this strategy provides a simple and practical method to overcome the drawbacks of traditional wound dressings,and provides further options when choosing suitable wound healing materials for clinical applications.
基金
This work was supported by National Natural Science Foundation of China(31800833 and 21977081)
Zhejiang Provincial Natural Science of Foundation of China(LZ19H180001 and LQ19C100001)
University of Chinese Academy of Sciences(WIBEZD2017001-03 and WIUCASYJ2020001-2)
Wenzhou Medical University(KYYW201901 and KYYW201906)
Wenzhou Science and Technology Plan Project(Y20180071)
Start-up Scientific Research Foundation of Wenzhou Medical University(KYQD20190513).
