摘要
缺血再灌注损伤(IRI)发生于缺血组织或器官恢复血液灌注后,炎症损伤是其主要病理机制之一,主要与自由基生成增多、细胞内钙超载和炎症反应过度激活有关。中药紫草素是一种天然萘醌类药物,临床应用广泛,具有抗炎、抗氧化、抗癌、免疫调节、血管保护等药理作用。紫草素的保护作用主要集中在减轻组织水肿和细胞坏死、抑制炎症细胞聚集激活、减少炎症细胞因子释放以及抑制细胞凋亡和自噬等方面,目前尚无紫草素单体临床应用的报道。因此,探究紫草素单体在IRI中保护作用的详细机制及其临床应用是未来研究的方向。
Ischemia reperfusion injury(IRI)follows the restoration of blood perfusion to the ischemic tissues and organs,and inflammatory injury is one of the main pathological mechanisms,which is mainly related to the increased generation of free radical,intracellular calcium overload and excessive activation of inflammatory reaction.Shikonin is a natural naphthoquinone drug,which has a broad range of clinical applications.It has many pharmacological effects,such as anti-inflammation,anti-oxidation,anti-cancer,immune regulation,vascular protection and so on.The studies on protective effects of shikonin are mainly focused on reducing tissue edema and necrosis,inhibiting the accumulation and activation of inflammatory cells,reducing the release of inflammatory cytokines,inhibiting apoptosis and autophagy,while no clinical application of shikonin monomer has been reported so far.Therefore,to explore the detailed mechanism of shikonin′s protective effect in IRI and its clinical application is the direction of future research.
作者
胡伟
曹磊
董岩
付生军
杨立
HU Wei;CAO Lei;DONG Yan;FU Shengjun;YANG Li(Department of Urology,Lanzhou University Second Hospital,Lanzhou 730030,China)
出处
《医学综述》
CAS
2021年第12期2441-2445,共5页
Medical Recapitulate
基金
甘肃省自然科学基金(17JR5RA237)
兰州大学第二医院“萃英科技创新”计划(CY2018-BJ02)。
关键词
缺血再灌注损伤
紫草素
中草药
炎症
Ischemia reperfusion injury
Shikonin
Chinese herbal
Inflammation
