摘要
目的探讨子痫前期并发胎儿生长受限(fetal growth restriction,FGR)的临床特征及母儿结局。方法回顾性分析2009年1月1日至2019年12月31日在广州医科大学附属第三医院产科就诊并分娩的单胎子痫前期患者的病例资料,根据是否合并FGR,分为FGR组和对照组,分析两组的临床特征及母儿结局。结果(1)2960例单胎子痫前期患者合并FGR的发生率为20.68%,早发型及晚发型子痫前期合并FGR的发生率分别为30.3%及13.7%(P<0.05);(2)两组受教育程度、妊娠次数、受孕方式及入院类型比较差异均有统计学意义(P均<0.05);(3)FGR组活产分娩孕周[(33.44±3.13)周]明显小于对照组[(35.82±3.78)周],FGR组死胎率(15.03%)、剖宫产率(80.39%)及住院天数[(9.21±4.70)d],均明显高于对照组[10.78%、71.12%、(8.45±6.34)d],FGR组胎儿窘迫(24.18%)、羊水过少(13.89%)的发生率明显高于对照组(10.09%、6.39%),差异均具有统计学意义(P<0.05);(4)FGR组≥28周不同孕周阶段的新生儿平均体重、平均身长及平均头围均低于对照组,FGR组新生儿窒息(21.0%)、新生儿呼吸窘迫(18.65%)、肺透明膜病(4.62%)、新生儿贫血(17.69%)的发生率都明显高于对照组(14.1%、10.60%、2.82%、7.97%),差异均具有统计学意义(P<0.05)。结论子痫前期与FGR的发生密切相关,子痫前期患者合并FGR时出现不良母儿结局的风险增加。
Objective To investigate the clinical features and maternal and neonatal outcomes of preeclampsia complicated with fetal growth restriction(FGR).Methods The clinical data of patients with preeclampsia,who were admitted to the Third Affiliated Hospital of Guangzhou Medical University from January 1,2009 to December 31,2019,were retrospectively analyzed.According to whether they were complicated with FGR,they were divided into FGR group and control group.The clinical characteristics and maternal and neonatal outcomes of two groups were analyzed.Results(1)The incidence of FGR in 2960 cases of preeclampsia was 20.68%.The incidences of FGR in early-onset and late-onset preeclampsia were 30.3%and 13.7%,respectively(P<0.05).(2)There were significant differences in educational level,gravidity,mode of conception and type of admission between the two groups(all P<0.05).(3)In FGR group,the gestational age of live birth(33.44±3.13)was significantly less than that in control group(35.82±3.78),the stillbirth rate(15.03%),cesarean section rate(80.39%)and hospital stay[(9.21±4.70)d]were significantly higher than those in control group[10.78%,71.12%,8.45±6.34(d)],the incidences of fetal distress(24.18%)and oligohydramnios(13.89%)in FGR group were significantly higher than those in control group(10.09%and 6.39%)(P<0.05).(4)The results showed that the average weight,length and head circumference of newborns in FGR group were lower than those in control group.The incidence of neonatal asphyxia(21.0%),neonatal respiratory distress(18.65%),pulmonary hyaline membrane disease(4.62%)and neonatal anemia(17.69%)in FGR group were significantly higher than those in control group(14.1%,10.60%,2.82%and 7.97%),the differences were statistically significant(P<0.05).Conclusions Preeclampsia is closely related to the occurrence of FGR.Preeclampsia patients complicated with FGR have an increased risk of adverse maternal and neonatal outcomes.
作者
陈娟娟
孙雯
苏春宏
林琳
周燕媚
余琳
杜丽丽
陈兢思
陈敦金
Chen Juanjuan;Sun Wen;Su Chunhong;Lin Lin;Zhou Yanmei;Yu Lin;Du Lili;Chen Jingsi;Chen Dunjin(Department of Obstetrics and Gynecology,The Third Affiliated Hospital of Guangzhou Medical University,Key Laboratory for Major Obstetric Diseases of Guangdong Province,Guangzhou Medical Center for Critical Pregnant Women,Guangzhou,510150,China)
出处
《中华产科急救电子杂志》
2021年第2期89-95,共7页
Chinese Journal of Obstetric Emergency（Electronic Edition）
基金
国家自然科学基金重点项目(81830045)。
关键词
子痫前期
胎儿生长受限
妊娠结局
Pre-eclampsia
Fetal growth restriction
Pregnancy outcome
