摘要
巨噬细胞作为免疫细胞,在非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)的发生发展过程中发挥着重要作用,极化方式的差异造成其功能的多样性,释放的炎症介质及信号通路与NASH等慢性肝病的发病机制密切相关。本文基于最新研究对巨噬细胞与NASH的相关性及发病机制作一综述,有望为NASH的治疗提供新的靶点。
Macrophages,as immune cells,play an important role in the occurrence and development of non-alcoholic stea-tohepatitis(NASH).Differences in their polarization patterns lead to diversity in their functions.The inflammatory mediators and signaling pathways released are closely related to the pathogenesis of NASH and other chronic liver diseases.Based on the latest studies,this paper summarizes the correlation and pathogenesis between macrophages and NASH,which is expected to provide new targets for the treatment of NAFLD and NASH.
作者
施铃灵
卞兆连
邵建国
SHI Lingling;BIAN Zhaolian;SHAO Jianguo(Department of Gastroenterology,Nantong Third Hospital Affiliated to Nantong University,Nantong 226006)
出处
《南通大学学报（医学版）》
2021年第2期161-164,共4页
Journal of Nantong University(Medical sciences)
基金
江苏省卫生厅科研基金资助项目(H2017057)。
关键词
非酒精性脂肪性肝炎
巨噬细胞
炎症因子
免疫
non-alcoholic steatohepatitis
macrophages
inflammatory cytokine
immunity
