摘要
目的探讨盐酸氨溴索与地塞米松治疗分泌性中耳炎的效果。方法选择2018年6月—2020年5月医院收治的84例分泌性中耳炎患者作为研究对象,以随机数字表法分为两组。两组患者均实施鼓膜穿刺排液治疗,对照组42例患者完成鼓膜穿刺排液治疗后,注入地塞米松磷酸钠注射液治疗,研究组42例患者注入地塞米松磷酸钠注射液与盐酸氨溴索治疗。对比两组临床疗效、治疗前后纯音听阈气导听力值与中耳积液的炎症因子[肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素-8(interleukin-8,IL-8)、白细胞介素-1β(interleukin-1β,IL-1β)、降钙素原(procalcitonin,PCT)]水平,以及不良反应情况。结果两组总有效率对比中,研究组95.24%较对照组76.19%更高(P<0.05)。治疗后,研究组0.5 kHz、1.0 kHz、2.0kHz频率下的气导听力值较对照组更低(P<0.01)。治疗后,研究组中耳积液TNF-α、IL-8、IL-1β、PCT水平较对照组更低(P<0.01)。不良反应发生率对比中,研究组4.76%与对照组4.76%对比差异无统计学意义(P>0.05)。结论盐酸氨溴索与地塞米松治疗分泌性中耳炎效果确切,有效改善了患者的听力水平,抑制炎症反应,安全可靠。
Objective To investigate the effect of ambroxol hydrochloride and dexamethasone in the treatment of secretory otitis media.Methods 84 patients with secretory otitis media from June 2018 to May 2020 in our hospital were selected as the research objects and randomly divided into two groups by random table.Two groups of patients were treated with tympanopentesis drainage treatment,42 patients in the control group were treated with dexamethasone sodium phosphate injection after completion of tympanopentesis drainage treatment,and 42 patients in the study group were treated with dexamethasone sodium phosphate injection and ambroxol hydrochloride.The clinical efficacy,pure tone threshold air conduction hearing value before and after treatment,and inflammatory factors in middle ear effusion[tumor necrosis factor alpha(TNF-α),interleukin-8(IL-8),interleukin-1β(IL-1β),procalcitonin(PCT)]levels,and adverse reactions.Results The total effective rate of the two groups was 95.24%higher than 76.19%of the control group(P<0.05).After treatment,the air conduction hearing values at 0.5 kHz,1.0 kHz and 2.0 kHz in the study group were lower than those in the control group(P<0.01).After treatment,the levels of TNF-α,IL-8,IL-1βand PCT in middle ear effusion of study group were lower than those of control group(P<0.01).There was no significant difference in the incidence of adverse reactions between the study group 4.76%and the control group 4.76%(P>0.05).Conclusion Ambroxol hydrochloride and dexamethasone are effective in the treatment of secretory otitis media,which can effectively improve the hearing level of patients and inhibit the inflammatory reaction,which is safe and reliable.
作者
付珍霞
FU Zhenxia(Department of Otorhinolaryngology,Second People’s Hospital of Chengyang District,Qingdao Shandong 266112,China)
出处
《中国卫生标准管理》
2021年第11期166-168,共3页
China Health Standard Management
关键词
盐酸氨溴索
地塞米松
分泌性中耳炎
听力
炎症因子
不良反应
ambroxol hydrochloride
dexamethasone
secretory otitis media
hearing
inflammatory factors
adverse reactions
