摘要
目的探讨西安地区中青年与老年急性轻型脑梗死(AMCI)患者的临床特征及1年预后情况。方法收集西安地区4所三级甲等医院AMCI患者的临床资料,按照年龄的不同分为老年组(≥65岁)和中青年组(18~<65岁),比较2组患者的临床资料。记录随访1年的结局事件,采用单因素和多因素回归分析评估2组AMCI患者的1年预后情况。结果本研究最终纳入AMCI患者933例,其中老年组444例,中青年组489例。中青年组与老年组患者在年龄、性别、文化程度、吸烟、饮酒、体质量指数、既往脑卒中史、合并肺炎、高血压、心房颤动、甘油三酯、高密度脂蛋白、肌酐、尿素氮等方面比较,差异均有统计学意义(P<0.05或P<0.01)。校正相关混杂因素后,多因素回归分析显示,与中青年组相比,老年组AMCI患者1年残障风险显著升高(HR=3.39,95%CI为1.91~6.03,P<0.001)。结论西安地区中青年与老年AMCI患者的临床特征存在较大差异,临床医师需重点关注老年人群AMCI,针对性地开展有效的预防和治疗措施,改善AMCI患者的预后。
Objective To investigate the clinical characteristics and 1-year prognosis of young and middle-aged as well as elderly patients with acute mild cerebral infarction(AMCI)in Xi’an area.Methods Clinical materials of AMCI patients in 4 gradeⅢlevel A hospitals in Xi’an area were collected.According to differed ages,the patients were divided into elderly group(aged 65 years and above)and young and middle-aged group(age of 18 to less than 65 years).Clinical materials of the two groups were compared.The outcome events of 1-year follow up were recorded,and univariate and multivariate regression analyses were used to investigate 1-year prognosis of patients in both groups.Results A total of 933 patients with AMCI were included in this study,including 444 cases in the elderly group and 489 cases in the young and middle-aged group.There were significant differences in age,gender,education level,smoking,drinking,body mass index,history of stroke,pneumonia,hypertension,atrial fibrillation,triglyceride,high density lipoprotein,creatinine and urea nitrogen between the young and middle-aged group and the elderly group(P<0.05 or P<0.01).After adjustment for the confounding factors,multivariate regression analysis showed that compared to the young and middle-aged group,the risk of 1-year disability in the elderly group significantly increased(HR=3.39,95%CI,1.91 to 6.03,P<0.001).Conclusion There are significant differences in clinical characteristics in young as well as middle-aged patients with AMCI in Xi’an area.Clinicians should focus on prevention of AMCI in the elderly people,and the effective prevention and treatment measures should be given to improve the prognosis of AMCI patients.
作者
王静
刘仲仲
逯青丽
刘佩
刘燕
常乔乔
张娜
蔺雪梅
王芳
吴松笛
WANG Jing;LIU Zhongzhong;LU Qingli;LIU Pei;LIU Yan;CHANG Qiaoqiao;ZHANG Na;LIN Xuemei;WANG Fang;WU Songdi(Department of Neurology,First Hospital Affiliated to Northwest University,Xi′an First Hospital in Shaanxi Province,Xi′an,Shaanxi,710002)
出处
《实用临床医药杂志》
CAS
2021年第7期34-38,共5页
Journal of Clinical Medicine in Practice
基金
陕西省科技计划项目(2017SF-163)
陕西省西安市科技计划项目[201805104YX12SF38(2),20YXYJ0008(1)]
陕西省西安市卫健委科研项目(2020ms03,2020yb05)。
关键词
老年
急性轻型脑梗死
临床特征
预后
elderly
acute mild cerebral infarction
clinical characteristic
prognosis
