摘要
文章以6,7,8-三氟-1,4-二氢-1-(N-甲基甲酰氨基)-4-氧代-3-喹啉羧酸乙酯为起始原料,经过偶联、脱醛、EschweilerClarke甲基化环合制备马波沙星粗品,最后精制得到马波沙星。在合成过程中N-甲基哌嗪偶联和脱醛反应同时进行,一步反应合成,无需中间步骤分离提纯。该工艺路线原料成本低,工艺安全环保,制备的产品与同类产品相比品质佳、性能优异,市场需求量大,竞争力强。
In this paper,marbofloxacin was prepared from ethyl 6,7,8-trifluoro-1,4-dihydro-1-(n-methylformylamino)-4-oxo-3-quinoline carboxylate via coupling,dealdehyde,eschweiler Clarke methylation and cyclization.In the synthesis process,N-methylpiperazine coupling and dealdehyde reaction were carried out at the same time.Compared with other similar products,the product has good quality,excellent performance,large market demand and strong competitiveness.
作者
张玲侠
ZHANG Ling-xia(Zhejiang Dinuo Environmental Protection Technology Co.,Ltd.,Hangzhou 310000,China)
出处
《化工管理》
2021年第17期158-159,共2页
Chemical Engineering Management
关键词
马波沙星
合成
工艺改进
marbofloxacin
synthesis
process improvement
