摘要
目的探究血浆N末端脑钠肽前体(NT-proBNP)水平对接受他汀类药物治疗急性心肌梗死(AMI)患者预后的评估价值。方法选取2018年11月至2019年11月我院收治的60例AMI患者(AMI组)和同期健康体检志愿者60名(对照组)为对象,依据AMI组预后不同分为主要不良心血管事件(MACE)发生组、无MACE组,比较AMI组、对照组一般资料、血浆NT-proBNP水平,观察治疗前后AMI组血浆NT-proBNP水平、血脂指标,比较不同预后AMI患者血浆NT-proBNP水平,分析血浆NT-proBNP水平与血脂指标的相关性,ROC曲线分析血浆NT-proBNP水平对AMI患者预后的预测价值。结果AMI组血浆NT-proBNP水平明显高于对照组(P<0.05);AMI组患者治疗后血浆NT-proBNP水平、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)水平明显降低,而高密度脂蛋白胆固醇(HDLC)明显升高,差异有统计学意义(P<0.05);AMI患者血浆NT-proBNP水平与血清TC、LDLC呈明显正相关(P<0.05)。随访发现共有12例发生MACE,48例未发生MACE,MACE发生组入院即刻血浆NT-proBNP水平较无MACE组明显高(P<0.05);血浆NT-proBNP水平预测接受他汀类药物治疗AMI患者预后的ROC曲线下面积为0.929,敏感度高,最佳临界值为510.539 pg/mL。结论血浆NT-proBNP水平在接受他汀类药物治疗AMI患者预后中的预测价值高且敏感度高,或可作为接受他汀类药物治疗AMI患者预后评估的有效标志物。
Objective To explore evaluation value of plasma N-terminal pro brain natriuretic peptide(NT-proBNP)level in prognosis of patients with acute myocardial infarction(AMI)treated with statins.Methods A total of 60 AMI patients(AMI group)who were admitted to the hospital from November 2018 to November 2019 and 60 healthy volunteers(control group)who underwent physical examination during the same period were enrolled as study subjects.According to different prognosis in AMI group,they were divided into MACE group and non-MACE group.The general data and level of plasma NT-proBNP were compared between AMI group and control group.The level of plasma NT-proBNP and blood lipid indexes before and after treatment in AMI group were observed.The levels of plasma NT-proBNP were compared among AMI patients with different prognosis.Correlation between level of plasma NT-proBNP and blood lipid indexes was analyzed.ROC curve analysis was applied to analyze predictive value of plasma NT-proBNP level for prognosis of AMI patients.Results The level of plasma NT-proBNP in AMI group was significantly higher than that in control group(P<0.05).After treatment,levels of plasma NT-proBNP,TC,TG and LDL-C were significantly decreased,while HDL-C was significantly increased in AMI group(P<0.05).The level of plasma NT-proBNP in AMI patients was significantly positively correlated with serum TC and LDL-C(P<0.05).It was found by follow-up that there were 12 patients with MACE,and 48 patients without MACE.The level of plasma NT-proBNP immediately after admission in MAC group was significantly higher than that in non-MACE group(P<0.05).There was no significant difference in the other indexes between the two groups(P>0.05).The area under the ROC curve(AUC)of plasma NT-proBNP level for predicting prognosis in AMI patients treated with statins was 0.929,with high sensitivity.And its optimal cutoff value was 510.539 pg/mL.Conclusion The predictive value and sensitivity are high for predicting prognosis in AMI patients treated with statins,which may be a
作者
孙晓臣
罗溶
刘海波
汪自龙
Sun Xiaochen;Luo Rong;Liu Haibo;Wang Zilong(Department of Cardiology,Qingpu Branch of Zhongshan Hospital,Fudan University,Shanghai201700,China)
出处
《山西医药杂志》
CAS
2021年第11期1800-1803,共4页
Shanxi Medical Journal
