摘要
目的:研究氟尿嘧啶+吡柔比星+奥沙利铂化疗联合三维强调放疗用于局部进展期胃癌根治术后的疗效及安全性。方法:回顾性分析2013年3月~2015年10月在我院接受治疗的84例局部进展期胃癌的临床资料,根据治疗方式的不同分为对照组和观察组,每组各42例。对照组患者入院后行胃癌根治术,术后予以氟尿嘧啶+吡柔比星+奥沙利铂化疗;观察组患者入院后行胃癌根治术,术后予以氟尿嘧啶+吡柔比星+奥沙利铂化疗,同时于第4个化疗周期后开始行三维适形调强放疗2周。观察两组治疗前后血清学指标(CEA、CA199、CA724、、CA125)以及治疗后1、2、3年总生存率及无进展生存率,比较两组治疗效果以及治疗期间不良反应发生率。结果:(1)观察组总有效率大于对照组(64.29%vs38.10%);(2)治疗前两组血清学指标比较无统计学意义,治疗后两组血清学指标(CEA、CA199、CA724、CA125)均有降低,且观察组比同期对照组降幅更明显;(3)观察组患者1、2、3年总生存率和1、2、3年无进展生存率均显著高于对照组,差异均有统计学意义;(4)治疗期间观察组不良反应率高于对照组,但差异无统计学意义。结论:氟尿嘧啶+吡柔比星+奥沙利铂化疗联合三维强调放疗用于局部进展期胃癌术后的疗效确切,可延长患者的生存时间,且安全性较好。
Objective To study the efficacy and safety of fluorouracil pirarubicin oxaliplatin chemotherapy combined with three dimensional radiotherapy for local advanced gastric cancer.Methods The clinical data of 84 cases of locally advanced gastric cancer treated in our hospital from March 2013 to October 2015 were analyzed retrospectively.According to the different treatment methods,they were divided into control group and observation group with 42 cases in each group.The patients in the control group received radical gastrectomy after admission,followed by fluorouracil + pirarubicin + oxaliplatin chemotherapy.The patients in the observation group received radical gastrectomy after admission,followed by fluorouracil + pirarubicin + oxaliplatin chemotherapy,3 D conformal intensity modulated radiotherapy (IMRT) was performed for 2 weeks after the fourth chemotherapy cycle.The serological index (CEA,CA199,CA724,CA125),the overall survival rate of 1 and 3 years and the progression-free survival rate were observed before and after treatment,and the therapeutic effect and the incidence of adverse reactions during the treatment were compared between the two groups.Results (1) The total effective rate in the observation group was higher than that in the control group (64.29% vs 38.10%),(2) There was no significant difference between the two groups in serological indexes before treatment,and in the two groups after treatment,the serological indexes (CEA、CA199、CA724、CA125) were not statistically significant.the decrease of CEA、CA199、CA724、CA125 in the observation group was more obvious than that in the control group.(3) The overall survival rate of 1 and 3 years and the 1 、2 and 3 year progression free survival rate in the observation group were significantly higher than those in the control group.(4) The adverse reaction rate in the observation group was higher than that in the control group,but the difference was not statistically significant.Conclusion Fluorouracil pirarubicin oxaliplatin chemotherapy combined wi
作者
蔺梅
印海林
李爱峰
Lin Mei;Yin Hai-lin;Li Ai-feng(Department of Oncology,People's Hospital of Lianshui County,Lianshui 223400,China)
出处
《湖南师范大学学报（医学版）》
2021年第1期183-186,共4页
Journal of Hunan Normal University(Medical Sciences)
关键词
氟尿嘧啶
吡柔比星
奥沙利铂
三维强调放疗
进展期胃癌
fluorouracil
pirarubicin
oxaliplatin
three dimensional emphasis radiotherapy
advanced gastric carcinoma
