摘要
目的:观察丹参注射液辅助孟鲁司特钠治疗小儿过敏性紫癜(HSP)的疗效及对免疫功能的影响。方法:将HSP患儿70例按随机数字表法分为观察组与对照组(各35例),2组患儿入院后均给予常规对症治疗,在此基础上,对照组给予孟鲁司特钠治疗,观察组在对照组基础上给予丹参注射液治疗,连续治疗14 d后记录2组临床疗效、症状改善情况及免疫功能指标变化。结果:观察组临床总有效率为91.43%,对照组临床总有效率为71.43%(P<0.05)。观察组皮肤紫癜消失时间、腹痛消失时间、关节疼痛消失时间、呕吐消失时间及肾损害消失时间均早于对照组(P<0.05)。治疗前,2组T淋巴细胞CD3^(+)、CD3^(+)/CD4^(+)、CD19^(+)表达率比较,差异无统计学意义(P>0.05)。治疗后,2组CD3^(+)、CD3^(+)/CD4^(+)表达率较治疗前上升,观察组CD3^(+)、CD3^(+)/CD4^(+)表达率上升幅度大于对照组(P<0.05);治疗后2组CD19^(+)表达率较治疗前下降,观察组CD19^(+)表达率低于对照组(P<0.05)。结论:丹参注射液辅助孟鲁司特钠治疗小儿HSP疗效确切,可明显缓解患儿临床症状,提高患儿机体免疫力。
Objective:To observe the curative effect of Danshen Injection combined with montelukast sodium on children with hypersensitive purpura(HSP) and its effect on immune function. Methods: A total of 70 cases of HSP children were divided into the observation group and the control group according to the random number table method,35 cases in each group. Both groups were given routine symptomatic treatments after admission;the control group was additionally treated with montelukast sodium,and the observation group was additionally given Danshen injection based on the treatment of the control group. Both groups were continuously treated for 14 days. The clinical effect,the improvement of symptoms,and changes in indexes of immune function were recorded in the two groups. Results:The total effective rate was 91.43% in the observation group, and 71.43% in the control group(P<0.05). The disappearance time of purpura, abdominal pain, joint pain, vomiting and the kidney injury in the observation group was earlier than that in the control group(P<0.05). Before treatment,when compared the expression rates of T lymphocytes CD3^(+),CD3^(+)/CD4^(+)and CD19^(+)between the two groups,there was no significance being found in the difference(P>0.05). After treatment,the expression rates of CD3^(+)and CD3^(+)/CD4^(+)in the two groups were increased when compared with those before treatment,and the increase of two rates in the observation group was greater than that in the control group(P<0.05). After treatment,the expression rates of CD19^(+)in the two groups were decreased when compared with those before treatment,and the expression rate in the observation group was lower than that in the control group(P<0.05). Conclusion:The therapy of Danshen Injection combined with montelukast sodium has defined curative effect in the treatment of children with HSP,which can effectively relive their clinical symptoms and improve the immunity of body.
作者
潘锋君
刘晟
PAN Fengjun;LIU Sheng
出处
《新中医》
CAS
2021年第11期92-95,共4页
New Chinese Medicine
关键词
过敏性紫癜
小儿
丹参注射液
孟鲁司特钠
免疫功能
Hypersensitive purpura
Children
Danshen injection
Montelukast sodium
Immune function
