摘要
目的探讨血清超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)浓度与非ST段抬高型急性冠状动脉综合征(non-ST-segment elevation acute coronary syndrome,NSTE-ACS)合并多支血管病变成功接受经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗患者长期预后的关系。方法2010年1月至2014年12月,在广东省人民医院南海医院连续入组了2583例诊断为NSTE-ACS合并多支血管病变并成功接受PCI治疗的患者,其均在入院时检测了血清hs-CRP浓度。跟踪随访患者3年,主要终点为全因死亡。结果3年随访期间,共发生了144例(5.6%)患者死亡。Hs-CRP第四分位组(>7.5 mg/L)患者3年全因病死率最高(9.2%),与其他浓度组患者比较,差异有统计学意义(P<0.001)。多因素回归分析结果表明,hs-CRP浓度升高与3年全因死亡风险升高显著相关(校正OR=1.01,95%CI:1.00~1.02,P=0.002)。结论入院时血清hs-CRP浓度升高与NSTE-ACS合并多支血管病变接受PCI治疗患者的3年全因病死率相关。
Objectives To find out the association between serum concentration of high sensitivity C-reactive protein(hs-CRP)and long-term prognosis in non-ST segment elevation acute coronary syndrome(NSTE-ACS)patients with multivessel coronary artery disease(MCAD)who received percutaneous coronary intervention(PCI).Methods We consecutively enrolled 2583 patients with diagnosis of NSTE-ACS with MCAD from January 2010 to December 2014 in Guangdong Provincial People′s Hospital′s Nanhai Hospital.Serum concentration of hs-CRP of these patients was tested on admission.The primary outcome was 3-year follow-up all-cause death.Results A total of 144(5.6%)deaths occurred during 3-year follow-up.The fourth quartile group of hs-CRP(>7.5 mg/L)had the highest long-term all cause mortality(9.2%)(P<0.001).Logistic analysis showed that increasing serum concentration of hs-CRP significantly associated with a higher risk of long-term all-cause death(adjusted OR=1.01,95%CI:1.00-1.02,P=0.002).Conclusions Raised serum concentration of hs-CRP strongly correlated with a high risk of long-term mortality in NSTE ACS patients with MCAD undergoing PCI.
作者
何文飞
林泽获
刘远辉
曾莉欢
何鹏程
HE Wen-fei;LIN Ze-huo;LIU Yuan-hui;ZENG Li-huan;HE Peng-cheng(Department of Cardiology,Guangdong Provincial People′s Hospital′s Nanhai Hospital,the Second People′s Hospital of Nanhai District,Foshan,Guangdong 528000,China;Shantou University Medical College,Shan-tou,Guangdong 515041,China;Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People′s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510100,China;School ofMedicine,Southern Medical University,Guangzhou 510100,China)
出处
《岭南心血管病杂志》
CAS
2021年第3期259-264,共6页
South China Journal of Cardiovascular Diseases
