摘要
目的对乙肝肝硬化患者采用恩替卡韦结合中药复方治疗,并分析其治疗效果。方法选取2018年10月至2019年9月西安市临潼区中医院乙肝肝硬化患者60例,将其分为研究组和对照组各30例,研究组采用恩替卡韦联合中药复方治疗,对照组采用恩替卡韦治疗。对比两组患者在治疗前后的肝功能指标ALT、Alb和TbiL,以及乙肝病毒基因(HBV-DNA)水平和治疗后的转阴率。结果与治疗前相比,两组患者肝功能指标ALT、Alb和TbiL,以及HBV-DNA水平均得到改善,且研究组肝功能指标ALT、Alb、TbiL和HBV-DNA水平均低于对照组(P<0.05);研究组HBV-DNA转阴率高于对照组(P<0.05)。结论采用恩替卡韦结合中药复方在治疗乙肝肝硬化,能有效地改善患者的肝功能,降低HBV-DNA水平,促使HBV-DNA转阴,具有显著效果。
Objective To analyze the effect of entecavir combined with traditional Chinese medicine in the treatment of patients with hepatitis B and liver cirrhosis.Methods From October 2018 to September 2019,60 patients with hepatitis B liver cirrhosis in the Lintong District Hospital of Xi′an City were selected and divided into a study group and a control group,30 cases respectively.The study group was treated with entecavir combined with traditional Chinese medicine,and the control group was treated with entecavir.The liver function indexes ALT,Alb and TbiL of the two groups of patients before and after treatment,as well as the level of hepatitis B virus gene(HBV-DNA)and the rate of negative conversion after treatment were compared.Results Compared with before treatment,the liver function indexes ALT,Alb and TbiL and HBV-DNA levels of the two groups of patients were improved,and the liver function indexes ALT,Alb,TbiL and HBV-DNA levels of the study group were lower than the control group(P<0.05);The HBV-DNA conversion rate of patients in the study group was higher than that in the control group(P<0.05).Conclusion Entecavir combined with traditional Chinese medicine preparations in the treatment of hepatitis B cirrhosis can effectively improve the liver function of patients,reduce the level of HBV-DNA,and promote HBV-DNA to turn negative,which has a significant effect.
作者
凌佩
李传根
LING Pei;LI Chuan-gen(Xi′an Lintong District Hospital of Traditional Chinese Medicine,Xi′an 710699;Ankang People′s Hospital,Ankang 725700,China)
出处
《延安大学学报（医学科学版）》
2021年第2期51-53,共3页
Journal of Yan'an University:Medical Science Edition
关键词
恩替卡韦
中药复方
乙肝肝硬化
肝功能
HBV-DNA
Entecavir
Traditional Chinese medicine
Hepatitis B cirrhosis
Liver function
HBV-DNA
